Astros vs. Pirates odds, line, start time, picks, best bets for June 3 matchup from proven model

The Pittsburgh Pirates (22-38) and the Houston Astros (32-27) are slated to square off in the first matchup of their three-game series on Tuesday. The Pirates have dropped two of their past three games, while Houston secured victories in two of their last three matchups. Lance McCullers Jr. (0-1, 5.89 ERA) will start for Houston. Paul Skenes (4.5, 2.15 ERA) is on the mound for the Pirates.

First pitch is scheduled for 6:40 p.m. ET at PNC Field in Pittsburgh. The Pirates are the -159 money-line favorites (bet $159 to win $100) in the latest Astros vs. Pirates odds, while the Astros are +135 underdogs (bet $100 to win $135). The over/under for total runs scored is 7.5 in the latest MLB odds. 

Before you make any Astros vs. Pirates picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 11 of the 2025 MLB season on a 13-10 run on top-rated MLB money-line picks. Anybody following could have seen strong returns!

The model has simulated Astros vs. Pirates 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

Who wins Astros vs. Pirates, and which side of the money line has all the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 13-10 roll on top-rated MLB picks!