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Astros vs. Phillies odds, lines: Advanced computer model reveals picks for Thursday's World Series Game 5

SportsLine's Projection Model has generated picks for Thursday's World Series Game 5 matchup between the Houston Astros and Philadelphia Phillies
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After getting no-hit on Wednesday, the Philadelphia Phillies (87-75) look to rebound when they take on the Houston Astros (106-56) in Game 5 of the World Series on Thursday night. It was just the second no-hitter in World Series history. The last one was by Don Larsen in Game 5 of the 1956 series against the Brooklyn Dodgers. Houston, which won the American League pennant, is looking for its first World Series championship since 2017. The Phillies, meanwhile, have not won a title since 2008, and are taking part in their first World Series since 2009.

First pitch from Citizens Bank Park in Philadelphia is set for 8:03 p.m. ET. Houston is listed as a -160 favorite (risk $160 to win $100) on the money line in the latest Astros vs. Phillies odds from Caesars Sportsbook, while the over/under for total runs scored is 7.5 (see the latest lines for every game on our MLB odds page).

Before making any Astros vs. Phillies picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it entered the 2022 World Series on a 20-13 roll on top-rated MLB money-line picks, returning more than $400. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen HUGE returns!

The model knows Houston will send American League Cy Young Award candidate Justin Verlander (18-4, 1.75 ERA) to the mound. Verlander, who struggled in Game 1, giving up five earned runs on six hits in five innings, is 1-0 this postseason. The right-hander defeated the New York Yankees 4-2 in Game 1 of the American League Championship Series. He allowed just one run on three hits with one walk and 11 strikeouts in six innings of work. In three postseason games, Verlander has walked four, while striking out 19.

The model also knows Philadelphia designated hitter Bryce Harper has been red hot this postseason, hitting six home runs with 13 RBI in 15 games. His two-run homer in Game 3 helped boost the Phillies to a 7-0 win over the Astros. He hit .400 in the NLCS win over the Padres, hitting two homers and driving in five runs, and hit .500 in the NLDS win over the Atlanta Braves, including two homers and five RBIs. He had an 11-game hitting streak snapped in Game 2 of the World Series, but has hits in 12 of 15 postseason games.

Now, it has set its sights on Astros vs. Phillies. We can tell you the model is leaning Over on the total, and it also says one side of the money line has ALL the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins World Series Game 5 Astros vs. Phillies? And which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the Astros vs. Phillies run line you should be all over on Thursday, all from the model on a roll on MLB picks!

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SportsLine Staff

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