Astros vs. Guardians odds, line, prediction: 2026 MLB picks for Monday, April 20 from proven model

A pair of American League potential contenders will meet on Monday's MLB schedule as the Houston Astros visit the Cleveland Guardians. Houston (8-15) has dropped four in a row, including getting swept by St. Louis over the weekend. Cleveland (13-10) is coming off back-to-back victories, last defeating Baltimore on Sunday. Spencer Arrighetti (1-0, 1.50 ERA) will make his second start of the year for Houston, while Slade Cecconi (0-2, 5.03 ERA) makes his fifth start for the Guardians. Cleveland has defeated Houston in four straight meetings.

First pitch is at 6:10 p.m. ET from Progressive Field in Cleveland. The latest Guardians vs. Astros odds list Cleveland as the -114 favorite on the money line (risk $114 to win $100). The over/under for total runs is 8.

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