Arkansas vs. Arizona odds, prediction: 2026 NCAA Tournament picks from proven model

The fourth-seeded Arkansas Razorbacks take on the top-seeded Arizona Wildcats in an NCAA Tournament West Region Sweet 16 matchup on Thursday. Arkansas is coming off a 94-88 last-second victory over potential Cinderella High Point on Saturday in the second round, while Arizona defeated Utah State 78-66 on Sunday. The Razorbacks (28-8), who won the SEC Conference tournament, have won seven in a row. The Wildcats (34-2), who won the Big 12 Conference and conference tournament, have won eleven straight. 

Tip-off from SAP Center at San Jose is set for 9:45 p.m. ET. Arkansas leads the all-time series 6-2, but the teams have not played each other in nearly 30 years. Arizona is a 7.5-point favorite in the latest Arkansas vs. Arizona odds, while the over/under for total points scored is 166.5. Before making any Arizona vs. Arkansas picks, you NEED to see the basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered the 2026 Sweet 16 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on a 28-22 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Arkansas vs. Arizona 10,000 times and the results are in. The model is going Under on the total, and it also says one side of the spread hits in well over 50% of the simulations!

So who wins Arkansas vs. Arizona, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!