Arizona vs. New Mexico odds, line, spread: Computer model reveals college football picks, predictions for Week 1, 2024

The No. 21 Arizona Wildcats look to continue the nation's second longest active winning streak (seven games) as they host the New Mexico Lobos on Saturday night. Arizona finished last season 10-3 but lost head coach Jedd Fisch and several notable players to Washington in the transfer portal. But new head coach Brent Brennan was able to keep star quarterback Noah Fifita and wide receiver Tetairoa McMillian, giving Arizona one of the most potent offenses in the Big 12 Conference. Meanwhile, New Mexico opened the Bronco Mendenhall era in Week 0, blowing a 31-14 fourth quarter lead, losing 34-31 to FCS Montana State.

Kickoff from Arizona Stadium is scheduled for 10:30 p.m. ET. The Wildcats are 31.5-point favorites in the latest Arizona vs. New Mexico odds from SportsLine consensus, while the over/under for total points scored is 58.5. Before making any Wildcats vs. Lobos picks or CFB predictions, you need to see what the SportsLine Projection Model has to say.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks. Anyone who has followed it has seen STRONG returns!

The model knows that Arizona was a perfect 6-0 when favored last season. Betting on them to win was the most profitable play last year, as bettors who put $100 on that outcome in every game walked away with nearly 3.5x their investment. 

The model has simulated Arizona vs. New Mexico 10,000 times and the results are in. We can tell you the model is leaning Over on the total, and it also says one side of the spread hits more than 70% of the time!

Who wins Wildcats vs. Lobos, and which side of the spread hits more than 70% of the time? Join SportsLine right now to find out which side of the spread you should be all over, all from the model on a 13-9 roll on top-rated CFB picks!