Arizona vs. BYU odds, prediction: 2026 Big 12 men's college basketball picks from proven model

The highlight contest on Wednesday's college basketball schedule is a ranked matchup between the Arizona Wildcats and BYU Cougars. No. 4 Arizona (23-2, 10-2 Big 12) dropped from the top spot in the AP Poll following back-to-back losses last week. No. 23 BYU (19-6, 7-5 Big 12) has won two in a row behind star freshman A.J. Dybantsa, which follows a four-game losing streak. The Wildcats lead the all-time series, 22-20.

Tipoff is at 9 p.m. ET from the McKale Memorial Center Coliseum in Tucson, Ariz. The Wildcats are 12.5-point favorites in the latest BYU vs. Arizona odds from DraftKings Sportsbook, while the over/under for total points scored is 162.5.

Before making any Arizona vs. BYU picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 16 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on a 13-7 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated BYU vs. Arizona 10,000 times and the results are in. The model is leaning Under, and it also says one side of the spread hits almost 70% of the time!

So who wins Arizona vs. BYU, and which side of the spread hits almost 70% of the time? Join SportsLine right now to see which side of the BYU vs. Arizona spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!