Angels vs. Indians odds, lines: Proven model reveals MLB picks, predictions for Aug. 22, 2021, Sunday Night Baseball matchup

The Cleveland Indians go for the three-game series sweep when they take on the Los Angeles Angels on ESPN's Sunday Night Baseball. The Indians have won seven straight home games against the Angels, and they are the "home" team here but the game is from Williamsport, Pa., for the Little League Classic (if it's not rained out). First pitch from BB&T Ballpark at Historic Bowman Field is at 7:08 p.m. ET. 

The Indians are listed as -121 favorites (risk $121 to win $100) on the money line in the latest Angels vs. Indians odds from Caesars Sportsbook, while the over-under for total runs scored is nine (see the latest lines for every game on our MLB odds page).

Before making any Angels vs. Indians picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, is 158-132 on top-rated MLB money-line picks through 20 weeks in the 2021 season, returning over $200. It also had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. Anyone following it has seen some HUGE returns!

Now, it has set its sights on Angels vs. Indians. We can tell you the model is projecting 9.7 total runs, and it also says one side of the money line has all the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins Angels vs. Indians? And which side of the money line has all the value? ... Join SportsLine right now to find out which side of the Angels vs. Indians money line you should be all over on Sunday Night Baseball, all from the model that is 158-132 on top-rated MLB money-line picks in 2021!