Alabama vs. Hofstra odds, prediction: 2026 NCAA Tournament picks from proven model

The 2026 NCAA Tournament continues with 16 more games on Friday, and one of the afternoon slots features the No. 4 seed Alabama taking on No. 13 Hofstra in the Midwest Region. Alabama went 23-9 overall and 13-5 in the SEC, while Hofstra went 24-10 overall and 12-6 in the CAA on its way to winning the conference tournament and the automatic bid. The winner advances to take on the winner of Texas Tech vs. Akron.

Tipoff from Benchmark International Arena in Tampa, Fla., is at 3:15 p.m. ET. The Tide are 14.5-point favorites in the latest Alabama vs. Hofstra odds, while the over/under is 160.5. 

Before making any Hofstra vs. Alabama picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered the 2026 NCAA Tournament on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on a 28-22 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Hofstra vs. Alabama 10,000 times and the results are in. The model is going Over on the total, and it also says one side of the spread hits more than 60% of the time!

So who wins Alabama vs. Hofstra, and which side of the spread hits more than 60% time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!