The San Francisco 49ers will take on the Los Angeles Rams in a key NFC West matchup on Sunday Night Football. Kickoff from Levi's Stadium in Santa Clara, Calif., is set for 8:20 p.m. ET. Los Angeles is a 2.5-point favorite in the latest Rams vs. 49ers odds from William Hill, while the over-under is 51.5. Before you make any Rams vs. 49ers picks, you NEED to check out the latest NFL predictions from the SportsLine Projection Model. 

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception five-plus years ago. It's off to a strong 10-5 roll on top-rated NFL picks this season. The model enters Week 6 on an incredible 106-70 run on top-rated NFL picks that dates back to the 2017 season.

The model ranked in the Top 10 on NFLPickWatch in three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is WAY UP.    

Now, it has set its sights on Rams vs. 49ers. We can tell you it's leaning Under, and it also says one side of the spread cashes in well over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any NFL picks of your own.

So who wins Rams vs. 49ers on Sunday Night Football? And which side of the spread hits in well over 50 percent of simulations? ... Join SportsLine right now to find out which side of the Rams vs. 49ers spread you should be all over, all from the advanced model that has returned over $7,500 on top-rated NFL picks!