76ers vs. Cavaliers prediction, odds, line: Proven model reveals 2026 NBA picks for Jan. 16

Eastern Conference contenders meet for the second time in three days as the Cleveland Cavaliers (23-19) visit the Philadelphia 76ers (22-17).. Cleveland won 133-107 when these teams met in Philly on Wednesday. 

Tipoff is at 7 p.m. ET from Xfinity Mobile Arena in Philadelphia. The latest Cavaliers vs. 76ers odds list Philly as the 1.5-point favorite, while the over/under is 235.5. 

Before making any 76ers vs. Cavaliers picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model enters Week 13 of the 2025-26 NBA season on a sizzling 34-15 roll on top-rated NBA spread picks dating back to last season. Anyone following could have seen HUGE returns!

The model has simulated Cavaliers vs. 76ers 10,000 times and the results are in. The model is going Over on the point total, and it also says one side of the spread hits in almost 70% of simulations!

Who wins 76ers vs. Cavaliers, and which side of the spread hits almost 70% of the time? ... Join SportsLine right now to find out which side of the Cavaliers vs. 76ers spread you should be all over, all from the model on a 34-15 roll on top-rated NBA spread picks!