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49ers vs Titans odds, Thursday Night Football spread: Proven model reveals NFL picks, predictions for TNF

SportsLine's Projection Model simulated 49ers vs. Titans 10,000 times and revealed its Week 16 NFL picks
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The San Francisco 49ers (8-6) visit the Tennessee Titans (9-5) in a primetime battle on Thursday Night Football. San Francisco is currently on a two-game winning streak as the 49ers fight to secure a playoff spot in the NFC. The 49ers beat the Atlanta Falcons in Week 15, while Tennessee couldn't pull out a road victory against the Pittsburgh Steelers, falling 19-13. 

Kickoff from Nissan Stadium is set for 8:20 p.m. ET. San Francisco is favored by 3.5 points in the latest 49ers vs. Titans odds from Caesars Sportsbook, while the Over-Under is 45.5. Before making you make any 49ers vs. Titans picks, you NEED to check out the latest NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up over $7,000 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 16 of the 2021 season on an incredible 133-96 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

The model knows San Francisco receiver Deebo Samuel has been a game-changer. Samuel is currently sixth in the NFL with 1,088 receiving yards on 61 receptions. He has also reeled in five touchdowns. The 2019 second-round pick has produced four games with more than 100 yards receiving and has five straight games with a rushing touchdown.

The model also knows Tennessee edge rusher Harold Landry has been a strong presence off the edge. Landry leads the squad with 13 tackles for loss along with 11 sacks. The Boston College product has secured a sack in eight games thus far, including back-to-back two-sack performances against the Jacksonville Jaguars and Buffalo Bills. 

Now, the model has set its sights on 49ers vs. Titans on Thursday Night Football. We can tell you it's leaning Over the point total, and it also says one side of the spread has ALL the value! You ABSOLUTELY need to see it before locking in any 49ers vs. Titans picks of your own.

So who wins 49ers vs. Titans on Thursday Night Football? And which side of the spread has ALL the value? ... Join SportsLine right now to see which side of the 49ers vs. Titans spread to back, all from the dialed-in NFL model that's up over $7,000 on top-rated NFL picks!

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SportsLine Staff