49ers vs. Seahawks line, odds: Proven model releases spread pick for 2026 NFL divisional round matchup on Saturday

Division rivals square off with a spot in the NFC Championship Game on the line when the San Francisco 49ers battle the Seattle Seahawks in a divisional round matchup on Saturday. San Francisco advanced with a 23-19 Wild Card Weekend win at Philadelphia, while Seattle is coming off a bye after earning the NFC's top seed. The 49ers (12-5), who were the sixth seed after tying for second in the NFC West with the Los Angeles Rams, are 8-2 on the road this year. The Seahawks (14-3), who won their first NFC West title since 2020, are 6-2 on their home field this season.

Kickoff from Lumen Field in Seattle is set for 8 p.m. ET. The Seahawks lead the all-time series 32-24, but San Francisco has won seven of the last nine meetings. The teams have split two postseason matchups. The Seahawks are 7.5-point favorites in the latest 49ers vs. Seahawks odds, while the over/under for total points scored is 45.5 via DraftKings Sportsbooks. 

Before making any 49ers vs. Seahawks picks, you NEED to see which side the proven SportsLine projection model is on.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the 2026 NFL divisional round matchup on a 53-37 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has locked in another confident pick for 49ers vs. Seahawks.

We can tell you it's leaning Over the point total, but also says that one side of the spread hits over 50% of the time! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.

So who wins 49ers vs. Seahawks in the 2026 NFL divisional round, and which side of the spread hits over 50% of the time? ... Join SportsLine RIGHT NOW to see which side of the line to back, all from the model that has gone 53-37 on top-rated picks since 2024!