49ers vs. Panthers prediction, line, odds: Proven model releases spread pick for 2025 NFL Week 12 Monday Night Football

A pair of NFC playoff hopefuls will meet in the NFL Week 12 finale as the Carolina Panthers visit the San Francisco 49ers on 'Monday Night Football'. Carolina (6-5) has alternated wins and losses over its last four games, most recently defeating the Falcons, 30-27, last Sunday. San Francisco (7-4) has alternated wins and losses over its last eight games. The Niners knocked off the Cardinals, 41-22, in Week 11 in Brock Purdy's return.

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Kickoff is at 8:15 p.m. ET from Levi's Stadium in Santa Clara, Calif. The latest Panthers vs. 49ers odds have San Francisco as the 7-point favorites, and the over/under for total points scored is 49.

Before making any Panthers vs. 49ers picks, you NEED to see which side the proven SportsLine projection model is on.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 on a 48-33 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has locked in another confident pick for 49ers vs. Panthers on 'Monday Night Football.'

We can tell you it's leaning Over the point total, but also says that one side of the spread hits well over 50% of the time! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.

So who wins Panthers vs. 49ers, and which side of the spread hits well over 50% of the time? ... Join SportsLine RIGHT NOW to see which side of the 49ers vs. Panthers line to back, all from the model that has gone 48-33 on top-rated picks since 2024!

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month for $1 JOIN NOW.