Week 7 of the 2024 NFL season features several intriguing matchups, including a rematch of Super Bowl LVIII between the undefeated Kansas City Chiefs and the host San Francisco 49ers at Levi's Stadium on Sunday. Kansas City (5-0) won its second straight championship and third in five years by posting a 25-22 overtime victory against San Francisco (3-3) in February. It marked the second time the Chiefs defeated the 49ers for the Vince Lombardi Trophy during their current run, as they triumphed 31-20 in Super Bowl LIV. Sunday's showdown is the 10th Super Bowl rematch to take place the following regular season, with the champion winning six of the previous nine meetings.

Along with the Minnesota Vikings, Kansas City (5-0) is one of the two remaining unbeaten teams in the league and is coming off its bye after posting a 26-13 victory over the New Orleans Saints in Week 5. The Chiefs haven't tasted defeat since Week 16 of the 2023 season, winning 11 consecutive contests - including the playoffs - after dropping a 20-14 decision to the Las Vegas Raiders.

Kansas City dominated play against New Orleans in its last outing, outgaining the Saints 460-220 in total offense while possessing the football for nearly 40 minutes. Patrick Mahomes posted his first 300-yard performance of the season (331), Kareem Hunt ran for 102 yards and a touchdown and wideout JuJu Smith-Schuster hauled in seven passes for 130 yards.

The 49ers lost three of four contests before defeating the Seattle Seahawks 36-24 in Week 6. Brock Purdy threw three TD passes, including a pair to tight end George Kittle, as San Francisco racked up 483 yards of total offense. The triumph evened both teams' records at 3-3 but gave San Francisco the edge for first place in the NFC West.

These teams last met in the regular season in Week 7 of the 2022 campaign, when Mahomes threw for 423 yards and three touchdowns in Kansas City's 44-23 victory at San Francisco. The win gave the Chiefs a 9-7 advantage in the all-time series, including playoffs. For their Week 7 matchup on Sunday, the 49ers are 1.5-point favorites in the latest odds via SportsLine consensus, while the over/under for total points is 47.

We'll take you through every aspect of the 49ers-Chiefs game that you need to know before you lock in your bets, including SportsLine expert picks, props, trends, injury information and everything else that will help you know which plays are worth making for the contest.

Who wins Chiefs vs. 49ers in their Week 7 showdown, and what critical X-factor makes one side of the spread hit HARD? ... Join SportsLine right now to see everything you need to know about the game in Week 7 of the 2024 season!!