49ers vs. Buccaneers odds, picks, line, time: 2023 NFL Week 11 predictions from proven model

The San Francisco 49ers and the Tampa Bay Buccaneers are set to square off in an NFC battle at 4:05 p.m. ET on Sunday at Levi's Stadium. San Francisco is 6-3 overall and 3-1 at home, while Tampa Bay is 4-5 overall and 2-2 on the road. The Niners are favored by 13.5 points in the latest 49ers vs. Buccaneers odds via SportsLine consensus, and the over/under is set at 42 points.

Before entering any 49ers vs. Buccaneers picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 11 of the 2023 NFL season on an incredible 174-125 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 28-17 roll on top-rated NFL picks since Week 7 of last season. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

The model has simulated 49ers vs. Buccaneers 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in almost 60% of simulations!

So who wins 49ers vs. Buccaneers, and which side of the spread hits almost 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks!