The 2025 US Open men's semifinals have arrived, and there is a blockbuster showdown to open the action on Friday afternoon. Novak Djokovic, who has won a record 24 grand slams, will square off against red-hot Carlos Alcaraz. The Spaniard has reached the final in every tournament he has entered since his second-round exit in Miami early in the season.  

Friday's match is set to begin at 3 p.m. ET at Arthur Ashe Stadium in New York. Alcaraz is the -400 favorite in the latest US Open odds, while Djokovic is the +300 underdog. The over/under for total games is 36.5.   

Before making any US Open men's picks or predictions, be sure to see the 2025 US Open picks from tennis handicapper Jose Onorato.

Onorato grew up playing competitive tennis in Caracas, Venezuela. After coming to the U.S., he trained with famed coach Nick Bollettieri at IMG Academy in Florida and faced players like Robert Farah, now one of the world's top-ranked doubles players.

Onorato, who holds dual degrees in finance and economics from the University of Miami, does extensive research before placing any tennis bets. He studies current form, players' tendencies on a particular surface, weather conditions and many other relevant factors. That systematic approach has helped Onorato go 168-106-8 (+107.12 units) on his best bets since 2022. He correctly called Jannik Sinner in the 2024 US Open (+320) and the 2025 Australian Open (+160), Carlos Alcaraz (+130) in the 2025 French Open and Sinner again at 2025 Wimbledon (+180). Anybody following could've seen HUGE returns!

For the final grand slam tournament of the season, Onorato has broken down the latest men's semifinal odds and has identified his best bets. 

Onorato has thoroughly studied the men's semifinal match between Djokovic and Alcaraz and has identified multiple best bets! You ABSOLUTELY need to see what they are before locking in any 2025 US Open picks of your own!

So where does all the value lie at the US Open 2025, and what Alcaraz vs. Djokovic bets should you target? ... Join SportsLine right now to see Jose Onorato's predictions and analysis for the 2025 US Open men's semifinals, all from the tennis expert who is 168-106-9 since 2022!