2025 NFL Week 18 odds, score predictions: SportsLine AI reveals picks for every game

The NFL Week 18 schedule features two games on Saturday and 14 on Sunday, including a Sunday Night Football matchup between the Baltimore Ravens and Pittsburgh Steelers. The AFC North title and a playoff spot will be on the line when Derrick Henry and the Ravens battle Aaron Rodgers and the Pittsburgh Steelers. The NFC South championship will also be on the line when the Carolina Panthers take on the Tampa Bay Buccaneers on Saturday afternoon. The Ravens are favored by 3.5 points, while the Seahawks are 1-point favorites.

Sunday's largest spreads include Titans vs. Jaguars (-11.5), Colts vs. Texans (-10.5) and Dolphins vs. Patriots (-10.5). Besides the Seahawks vs. 49ers, the smallest spreads in Week 18 include Saints vs. Falcons (-2.5), Lions vs. Bears (-2.5) on Sunday and Panthers vs. Buccaneers (-3) on Saturday. Seattle entered the weekend as the NFC's top seed, while Denver remains in line for the top seed in the AFC.

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Before making any Week 18 NFL picks, be sure to check out the NFL score predictions from the SportsLine's self-learning AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data then quantitatively evaluating the strength of the opponents defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see a 5-star rating on an Over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine's AI has nailed more than 2,000 4.5- and 5-star prop picks since the start of the 2023 season! Anyone who has followed it is WAY UP!

After analyzing every game in Week 18, the AI says the Rams (-9.5), who have already clinched a playoff berth, cover comfortably against the Cardinals. Quarterback Matthew Stafford has played at an NFL MVP level this year. In 15 games, he has completed 65.6% of his passes for 4,179 yards and 40 touchdowns with five interceptions for a rating of 111.9.

SportsLine AI rates the Rams as a B+ spread pick and also predicts a 31-20 win on average.

SportsLine AI has generated against the spread, over/under and money-line picks for every game in Week 18! In fact, the AI has generated a dozen HIGHLY-COVETED A+ picks! You ABSOLUTELY NEED to see the AI analysis before making any Week 18 NFL bets.

Which NFL bets do you need to make NOW for Week 18? And which must-see NFL picks are worthy of an A+ rating? ... Join SportsLine now to see the top 2025 Week 18 NFL picks, all from the self-learning SportsLine AI that has nailed a COLOSSAL 2,000+ top-rated picks since the start of last season!

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