2025 NFL Week 17 odds, score predictions: SportsLine AI reveals picks for every game

The NFL Week 17 schedule features a full slate of games, including 10 on Sunday, several of which have a direct bearing on the NFL playoffs and seeding. In the NFC, the NFC West-leading Seattle Seahawks take on the NFC South-leading Carolina Panthers. Seattle enters as a -7.5 favorite. In the AFC South, the division-leading Jacksonville Jaguars take on the Indianapolis Colts. The Jaguars are favored by -6.5.

Sunday's largest spread is Patriots (-13.5) vs. Jets, while another larger spread is on Monday Night Football, with the Rams (-8.5) vs. Falcons. The smallest spreads Sunday include Giants vs. Raiders (-1.5), Saints (-2.5) vs. Titans, Eagles vs. Bills (-2.5) and Bears vs. 49ers (-2.5) on Sunday Night Football. Seattle entered the weekend as the NFC's top seed, while Denver was first in the AFC. 

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Before making any Week 17 NFL picks, be sure to check out the NFL score predictions from the SportsLine's self-learning AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data then quantitatively evaluating the strength of the opponents defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see a 5-star rating on an Over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine's AI has nailed more than 2,000 4.5- and 5-star prop picks since the start of the 2023 season! Anyone who has followed it is WAY UP!

After analyzing every game in Week 17, the AI says the Steelers (-4.5), who have won three in a row, cover comfortably against the Browns. Quarterback Aaron Rodgers has played well of late. In 14 games, he has completed 66.7% of his passes for 2,860 yards and 23 touchdowns with seven interceptions for a rating of 98.2.

SportsLine AI rates the Steelers as an A+ spread pick and also predicts a 24-15 win on average.

SportsLine AI has generated against the spread, over/under and money-line picks for every game in Week 17! In fact, the AI has generated more than two dozen HIGHLY-COVETED A+ picks! You ABSOLUTELY NEED to see the AI analysis before making any Week 17 NFL bets.

Which NFL bets do you need to make NOW for Week 17? And which must-see NFL picks are worthy of an A+ rating? ... Join SportsLine now to see the top 2025 Week 17 NFL picks, all from the self-learning SportsLine AI that has nailed a COLOSSAL 2,000+ top-rated picks since the start of last season!

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