2025 NFL Week 17 Bears-49ers line, odds: Expert reveals pick for matchup on Sunday Night Football

The San Francisco 49ers will look to move one step closer to earning the NFC West title and top seed in the conference when they take on the Chicago Bears on Sunday Night Football. Chicago is coming off a 22-16 overtime win over the Green Bay Packers on Dec. 20, while San Francisco defeated the Indianapolis Colts 48-27 on Monday. The Bears (11-4), who lead the NFC North, are 5-3 on the road this season. The 49ers (11-4), who are second in the NFC West, are 4-2 on their home field in 2025.

Kickoff from Levi's Stadium in Santa Clara, Calif., is set for 8:20 p.m. ET. San Francisco leads the all-time series 36-33-1, including wins in two of the last three meetings. The 49ers are 3-point favorites in the latest Bears vs. 49ers odds at DraftKings Sportsbook, while the over/under for total points scored is set at 51.5. The Niners are -168 favorites on the money line (risk $168 to win $100).

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Before making any Bears vs. 49ers picks, you NEED to see which side SportsLine NFL expert Micah Roberts is on, considering his mastery of 49ers picks.

Roberts has worked in the Las Vegas sportsbook industry for 20-plus years, including a 13-year run as Station Casinos' book director. Armed with an elaborate network of sources, Roberts has unmatched info in multiple sports. Roberts has a strong read on the pulse of the 49ers. He is 18-4 (+1360) on his last 22 against-the-spread picks in games involving San Francisco!

Now, Roberts has locked in another confident against-the-spread pick for Bears vs. 49ers.

We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

So who wins Bears vs. 49ers on Sunday Night Football, and what x-factor makes one side of the spread hit HARD? ... Join SportsLine right now to see which side of the Bears vs. 49ers spread to back, all from the expert who is a blistering 18-4 in his last 22 San Francisco 49ers picks!

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