2025 NFL Week 16 Rams vs. Seahawks prediction, line, odds: Expert reveals pick for matchup on Thursday Night Football

A pair of NFC West rivals will clash on 'Thursday Night Football' when the Los Angeles Rams visit the Seattle Seahawks. Both teams are 11-3, though L.A. owns the tiebreaker -- and has already clinched a playoff spot -- by virtue of its Week 11 victory over the Seahawks. The Rams have won two in a row, most recently defeating the Lions, 41-34, on Sunday. The Seahawks are riding a four-game win streak and are coming off an 18-16 triumph over Indianapolis in Week 15. The all-time series between the two is dead even at 28-28.

Kickoff is at 8:15 p.m. ET from Lumen Field in Seattle. The latest Rams vs. Seahawks odds have Los Angeles as the 1.5-point favorites. The over/under for total points scored is 44.5.

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Before making any Seahawks vs. Rams picks, you NEED to see which side SportsLine NFL expert Larry Hartstein is on, considering his mastery of NFL picks.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. Hartstein tied for 52nd place (out of 1,598 entries) in the 2022 Westgate Las Vegas SuperContest, going 53-34-3 ATS. He is coming off a down 2024 NFL season at SportsLine that puts him at 967-821 all-time on NFL sides and props (plus 13.8 units), including 593-518 ATS. Entering the 2025-26 season, he has been profitable in five of six seasons, going 659-564 ATS (plus $3,556 for $100 players). 

In addition, Hartstein has gone 27-10-1 on his last 38 ATS picks involving the Rams, returning $1,600. Anyone who has followed him could be WAY UP!

Now, Hartstein has locked in another confident against-the-spread pick for Rams vs. Seahawks.

We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

So who wins Seahawks vs. Rams on 'Thursday Night Football', and what x-factor makes one side of the spread hit HARD? ... Join SportsLine right now to see which side of the Rams vs. Seahawks spread to back, all from the expert who is a blistering 27-10-1 (+1601) on L.A. Rams picks!

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