A full 16-game slate highlights NFL Week 15, including a number of key divisional matchups. In an important AFC East battle, the New England Patriots (11-2) could clinch the division with a win over the Buffalo Bills (9-4). The Bills are favored by 1.5 points as Josh Allen of the Bills takes on Drake Maye of the Patriots, as New England is aiming for its 11th straight victory. A Buffalo win would allow the Bills to close within one game of first place with three games remaining.

A key non-divisional matchup in the NFC pits the Detroit Lions (8-5) against the NFC West-leading Los Angeles Rams (10-3). Detroit has won each of the last two meetings, but the Rams enter as the 5.5-point favorite. The Lions are coming off a 44-30 win over the Cowboys on Thursday Night Football, while the Rams crushed the Cardinals 45-17 on Sunday. Sunday's largest spreads are Titans vs. 49ers (-12.5), Raiders vs. Eagles (-12.5) and Colts vs. Seahawks (-11.5).

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Before making any Week 15 NFL picks, be sure to check out the NFL score predictions from the SportsLine's self-learning AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data then quantitatively evaluating the strength of the opponents defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see a 5-star rating on an Over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine's AI has nailed more than 2,000 4.5- and 5-star prop picks since the start of the 2023 season! Anyone who has followed it is WAY UP!

After analyzing every game in Week 15, the AI says the Cowboys (-6), who have won three of their last four games, cover comfortably against the Vikings. Quarterback Dak Prescott has been on a roll. In 13 games, he has completed 69% of his passes for 3,637 yards and 26 touchdowns with 10 interceptions for a rating of 100.2.

SportsLine AI rates the Cowboys as an A+ spread pick and also predicts a 30-20 win on average.

SportsLine AI has generated against the spread, over/under and money-line picks for every game in Week 15! In fact, the AI has generated more than two dozen HIGHLY-COVETED A+ picks! You ABSOLUTELY NEED to see the AI analysis before making any Week 15 NFL bets.

Which NFL bets do you need to make NOW for Week 15? And which must-see NFL picks are worthy of an A+ rating? ... Join SportsLine now to see the top 2025 Week 15 NFL picks, all from the self-learning SportsLine AI that has nailed a COLOSSAL 2,000+ top-rated picks since the start of last season!

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