2025 NFL Week 14 Cowboys vs. Lions prediction, line, odds: Expert reveals pick for matchup on Thursday Night Football

The two teams facing off on 'Thursday Night Football' in NFL Week 14 won't have to worry about playing on a short week, as they each were featured in separate Thanksgiving Day games. Lions vs. Cowboys will take place on TNF, with Detroit (7-5) coming off a 31-24 loss to Green Bay, while Dallas (6-5-1) entering in off a 31-28 win over Kansas City. The Lions are currently the eighth seed in the NFC standings, while the Cowboys are the ninth seed. CB Trevon Diggs (knee), OL Tyler Guyton (ankle) and EDGE Jadeveon Clowney (hamstring) have been ruled for for Dallas, while Amon-Ra St. Brown (ankle) is active for Detroit.

Kickoff is at 8:15 p.m. ET from Ford Field in Detroit. Dallas leads the all-time series, 19-13, but the Lions won the last matchup in 2024. Detroit is the 3.5-point favorite in the latest Cowboys vs. Lions odds, while the over/under for total points scored is 55.5. Detroit is at -181 on the money line (risk $181 to win $100), with Dallas at +151.

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Before making any Lions vs. Cowboys picks, you NEED to see which side SportsLine NFL expert R.J. White is on, considering his mastery of NFL picks.

White, a Fantasy and gambling editor for CBS Sports, consistently crushes against-the-spread picks and has gone 718-623-37 on his ATS picks from 2017-24, which returned more than $3,200 to $100 players. He is an OUTSTANDING 34-22-2 (+1064) over his last 58 picks in Lions games! Anyone who has followed him could be WAY up!

Now, White has locked in another confident against-the-spread pick for Cowboys vs. Lions.

We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

So who wins Lions vs. Cowboys on 'Thursday Night Football', and what x-factor makes one side of the spread hit HARD? ... Join SportsLine right now to see which side of the Cowboys vs. Lions spread to back, all from the expert who is a blistering 34-22-2 (+1064) on Detroit picks!

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