2025 NFL Week 13 odds, score predictions: SportsLine AI reveals picks for every game

NFL Week 13 features a 16-game slate, including a number of key divisional matchups. In an important AFC South battle, the Houston Texans look to pull within one game of the division lead when they meet the Indianapolis Colts. The Colts are favored by 3.5 points as C.J. Stroud will return after missing the last three games with a concussion.

A non-divisional matchup with heavy AFC playoff race implications will be played on Sunday afternoon when Josh Allen and the Buffalo Bills take on Aaron Rodgers, who missed last week with a wrist injury, and the Pittsburgh Steelers. Buffalo has won four of the past five meetings, with the Bills pulling out a 31-17 win in the last meeting on Jan. 15, 2024. Sunday's largest spreads are Vikings vs. Seahawks (-11.5), Rams (-10.5) vs. Panthers and Raiders vs. Chargers (-9.5).

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Before making any Week 13 NFL picks, be sure to check out the NFL score predictions from the SportsLine's self-learning AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data then quantitatively evaluating the strength of the opponents defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see a 5-star rating on an Over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine's AI has nailed more than 2,000 4.5- and 5-star prop picks since the start of the 2023 season! Anyone who has followed it is WAY UP!

After analyzing every game in Week 13, the AI says the Rams (-10.5), who have won six in a row, cover comfortably against the Panthers. Quarterback Matthew Stafford has played at an MVP-type level. In 11 games for Los Angeles, he has completed 66.5% of his passes for 2,830 yards and 30 touchdowns with two interceptions and a 113.7 rating.

SportsLine AI rates the Rams as an A+ spread pick and also predicts a 30-17 win on average.

SportsLine AI has generated against the spread, over/under and money-line picks for every game in Week 13! In fact, the AI has generated more than two dozen HIGHLY-COVETED A+ picks! You ABSOLUTELY NEED to see the AI analysis before making any Week 13 NFL bets.

Which NFL bets do you need to make NOW for Week 13? And which must-see NFL picks are worthy of an A+ rating? ... Join SportsLine now to see the top 2025 Week 13 NFL picks, all from the self-learning SportsLine AI that has nailed a COLOSSAL 2,000+ top-rated picks since the start of last season!

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