2025 NFL Week 13 Giants vs. Patriots line, odds: Expert reveals pick for matchup on Monday Night Football

The New England Patriots look to extend their winning streak to 10 games when they take on the New York Giants, who look to snap a six-game losing string, on 'Monday Night Football'. New York is coming off a 34-27 overtime loss at Detroit on Nov. 23, while New England downed Cincinnati 26-20 that same day. The Giants (2-10), who are fourth in the NFC East, are 0-7 and were the first team in the league to be eliminated from postseason consideration. The Patriots (10-2), first in the AFC East, are 4-2 on their home field. Quarterback Jaxson Dart (concussion) is expected to return for the Giants.

Kickoff from Gillette Stadium in Foxborough, Mass., is set for 8:15 p.m. ET. The all-time series is tied 7-7. The Patriots are 7.5-point favorites in the latest Giants vs. Patriots odds, while the over/under for total points scored is set at 46.5. 

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Before making any Giants vs. Patriots picks, you NEED to see which side SportsLine NFL expert R.J. White is on, considering his mastery of NFL picks.

White, a Fantasy and gambling editor for CBS Sports, consistently crushes against-the-spread picks and has gone 718-623-37 on his ATS picks from 2017-24, which returned more than $3,200 to $100 players. He is an OUTSTANDING 34-22-1 (+1027) on his last 57 New York Giants picks! Anyone who has followed him could be WAY up!

Now, White has locked in another confident against-the-spread pick for Giants vs. Patriots.

We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

So who wins Giants vs. Patriots on Monday Night Football, and what x-factor makes one side of the spread hit HARD? ... Join SportsLine right now to see which side of the Giants vs. Patriots spread to back, all from the expert who is a blistering 34-22-1 in his last 57 New York Giants picks!

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