2025 NFL Week 12 odds, score predictions: SportsLine AI reveals picks for every game

A 14-game slate is featured in NFL Week 12, including a number of matchups with playoff implications. Among the biggest is when the AFC South-leading Indianapolis Colts led by quarterback Daniel Jones face the nine-time defending AFC West champion Kansas City Chiefs and quarterback Patrick Mahomes. Both Indy and Kansas City are winless versus the spread over their last two games. A key NFC North battle pits the 4-6 Minnesota Vikings against the 6-3-1 Green Bay Packers. The Chiefs are -3.5, while the Packers are favored by -6.5, though Green Bay will be without Josh Jacobs (knee).

A non-divisional matchup with heavy NFC playoff race implications will be played on Sunday Night Football when the Tampa Bay Buccaneers meet the Los Angeles Rams. Los Angeles has won eight of the past 10 meetings, with Tampa Bay pulling out a 16-13 win in the last meeting on Nov. 6, 2022. Sunday's largest spreads are Jets vs. Ravens (-13.5), Seahawks (-13.5) vs. Titans and Giants vs. Lions (-12.5).

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Before making any Week 12 NFL picks, be sure to check out the NFL score predictions from the SportsLine's self-learning AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data then quantitatively evaluating the strength of the opponents defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see a 5-star rating on an Over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine's AI has nailed more than 2,000 4.5- and 5-star prop picks since the start of the 2023 season! Anyone who has followed it is WAY UP!

After analyzing every game in Week 12, the AI says the Seahawks (-13.5) cover comfortably against the Titans, who have lost five in a row. Quarterback Sam Darnold has played well in his first season in Seattle. In 10 games, he has completed 70.2% of his passes for 2,541 yards and 17 touchdowns with 10 interceptions and a 105 rating.

SportsLine AI rates the Seahawks as an A+ spread pick and also predicts a 30-14 win on average.

SportsLine AI has generated against the spread, over/under and money-line picks for every game in Week 12! In fact, the AI has generated more than a dozen HIGHLY-COVETED A+ picks! You ABSOLUTELY NEED to see the AI analysis before making any Week 12 NFL bets.

Which NFL bets do you need to make NOW for Week 12? And which must-see NFL picks are worthy of an A+ rating? ... Join SportsLine now to see the top 2025 Week 12 NFL picks, all from the self-learning SportsLine AI that has nailed a COLOSSAL 2,000+ top-rated picks since the start of last season!

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