2025 NFL Week 12 Bills vs. Texans line, odds: Expert reveals pick for matchup on Thursday Night Football

The Houston Texans eye their third consecutive win when they take on the Buffalo Bills in a key Thursday Night Football matchup. Buffalo is coming off a 44-32 win over the Tampa Bay Buccaneers, while Houston defeated the Tennessee Titans 16-13. The Bills (7-3), who are second in the AFC East, are 2-2 on the road this season. The Texans (5-5), who are third in the AFC South, are 3-2 on their home field. Houston quarterback C.J. Stroud (concussion) has been ruled out, paving the way for Davis Mills to make another start. Bills receiver Keon Coleman is inactive for the second straight week. Buffalo is 5-5 against the spread this season, while Houston is 4-6 versus the line.

Kickoff from NRG Stadium in Houston is set for 8:15 p.m. ET. Houston leads the all-time series 7-5 and has won five straight home meetings. The Bills are 5-point favorites in the latest Bills vs. Texans odds, after opening as 2.5-point favorites. The over/under for total points scored is 44.5. Buffalo is at -265 on the money line, with Houston at +215.

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Before making any Bills vs. Texans picks, you NEED to see which side SportsLine NFL expert R.J. White is on, considering his mastery of NFL picks.

White, a Fantasy and gambling editor for CBS Sports, consistently crushes against-the-spread picks and has gone 718-623-37 on his ATS picks from 2017-24, which returned more than $3,200 to $100 players. He is an OUTSTANDING 114-90-2 (+2078) on his last 204 NFL picks! Anyone who has followed him could be WAY up!

Now, White has locked in another confident against-the-spread pick for Bills vs. Texans.

We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

So who wins Bills vs. Texans on Thursday Night Football, and what x-factor makes one side of the spread hit HARD? ... Join SportsLine right now to see which side of the Bills vs. Texans spread to back, all from the expert who is a blistering 114-90 on NFL picks!

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