2025 NFL Week 11 odds, score predictions: SportsLine AI reveals picks for every game

The NFL Week 11 schedule features nine divisional clashes. Among the biggest are Sunday, when the AFC West co-leading Seattle Seahawks and Los Angeles Rams face off as Sam Darnold looks to guide the Seahawks past Matthew Stafford and the Rams. Both Seattle and Los Angeles sport 7-2 spread records this season. Another key divisional matchup features the Kansas City Chiefs taking on the Denver Broncos in a pivotal AFC West meeting. The Rams are -3.5, while Kansas City is favored by 4 points on the road, as the Chiefs are one of a half-dozen road favorites on Sunday.

A non-divisional matchup with heavy NFC playoff race implications features the Detroit Lions against the Philadelphia Eagles. Philadelphia has won the last two meetings, the last a 38-35 triumph in 2022. Sunday's largest spreads are Ravens (-7.5) against the Browns, the Packers (-7) vs. the Giants, as Jameis Winston will start for New York in place of Jaxson Dart (concussion), and the Texans (-5.5) vs. the Titans, as Davis Mills will start at QB for Houston in place of C.J. Stroud (concussion).

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Before making any Week 11 NFL picks, be sure to check out the NFL score predictions from the SportsLine's self-learning AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data then quantitatively evaluating the strength of the opponents defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see a 5-star rating on an Over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine's AI has nailed more than 2,000 4.5- and 5-star prop picks since the start of the 2023 season! Anyone who has followed it is WAY UP!

After analyzing every game in Week 11, the AI says the Cowboys (-3.5) cover comfortably against the Raiders, who have lost three in a row. Quarterback Dak Prescott has been playing at an elite level for Dallas. In nine games, he has completed 69.3% of his passes for 2,319 yards and 17 touchdowns with just six interceptions. He has also rushed 29 times for 121 yards and one score.

SportsLine AI rates the Cowboys as an A+ pick on the money line and also predicts a 29-21 win on average.

SportsLine AI has generated against the spread, over/under and money-line picks for every game in Week 11! In fact, the AI has generated well over 20 HIGHLY-COVETED A+ picks! You ABSOLUTELY NEED to see the AI analysis before making any Week 11 NFL bets.

Which NFL bets do you need to make NOW for Week 11? And which must-see NFL picks are worthy of an A+ rating? ... Join SportsLine now to see the top 2025 Week 11 NFL picks, all from the self-learning SportsLine AI that has nailed a COLOSSAL 2,000+ top-rated picks since the start of last season!

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