2025 NFL Week 11 Lions vs. Eagles line, odds: Expert reveals pick for matchup on Sunday Night Football

The Philadelphia Eagles will look to win their fourth game in a row and stay in contention for the NFC's top seed when they take on the NFC North-leading Detroit Lions on Sunday Night Football. Detroit is coming off a 44-22 win at Washington last Sunday, while Philadelphia held off the Green Bay Packers 10-7 on Monday night. The Lions (6-3), who are 3-2 in the conference, are also 3-2 on the road this year. The Eagles (7-2), who are 6-1 against NFC foes, are 3-1 on their home field. Sam LaPorta (back) is out and was recently placed on injured reserve by Detroit, while the Lions will also be without defensive backs Terrion Arnold (concussion) and Kerby Joseph (knee).

Kickoff from Lincoln Financial Field in Philadelphia is set for 8:20 p.m. ET. Philadelphia leads the all-time series 18-16-2, including nine of the last 13. The Eagles are 2.5-point favorites in the latest Lions vs. Eagles odds, while the over/under for total points scored is 46.5. Both the spread and the over/under have held steady since first opening. Philadelphia is -148 on the money line (risk $148 to win $100), while Detroit is +124 (risk $100 to win $124).

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Before making any Lions vs. Eagles picks, you NEED to see which side SportsLine NFL expert R.J. White is on, considering his mastery of picks involving the Lions.

White, a Fantasy and gambling editor for CBS Sports, consistently crushes against-the-spread picks and has gone 718-623-37 on his ATS picks from 2017-24, which returned more than $3,200 to $100 players. He is an OUTSTANDING 34-21-2 (+1177) on his last 57 picks in games involving the Lions! Anyone who has followed him is WAY up!

Now, White has locked in another confident against-the-spread pick for Lions vs. Eagles.

We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

So who wins Lions vs. Eagles on Sunday Night Football, and what x-factor makes one side of the spread hit HARD? ... Join SportsLine right now to see which side of the Lions vs. Eagles spread to back, all from the expert who is a blistering 34-21 on picks involving the Lions!

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