The American League will look to make it two wins in a row and 11 of the last 12 when they battle the National League in the 2025 MLB All-Star Game on Tuesday. The AL won last year's game 5-3, after the NL had snapped a nine-game losing streak in 2023. The AL holds a 48-44-2 all-time edge over the NL in the all-time series. In 94 games, the American League has outscored the National League 388-380. 

First pitch from Truist Park in Atlanta is set for 8 p.m. ET. Since 1997, the AL has gone is 22-4-1. The National League is a -132 favorite on the money line (risk $132 to win $100) in the latest 2025 MLB All-Star odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 7 in the latest MLB odds. The latest MLB home runs props have Shohei Ohtani (+600) and Aaron Judge (+650) as the two biggest favorites to go deep, followed by HR Derby champion Cal Raleigh (+700).

Before you make any 2025 MLB All-Star Game picks or MLB predictions, you need to see what SportsLine's Matthew Severance has to say.

Severance is a well-connected writer and handicapper who has worked in the industry since 2005. Over his past 293 MLB money line picks, he has gone 182-110-1 and is up $1,003. Anyone following could have seen huge returns!

We can tell you Severance is leaning Under on the run total, and also has found a critical x-factor that makes one side the value pick!

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