The 95th edition of the All-Star Game has the American League taking on the National League on Tuesday night. The AL has secured the win last year at the tune of 5-3. The American League has defeated the National League in nine of the last 10 All-Star games. They also lead the all-time series 48-44. Paul Skenes will start for the National League, with Tarik Skubal going for the American League.

First pitch from Truist Park in Atlanta is set for 8 p.m. ET. Since 1997, the AL has gone is 22-4-1. The National League is a -132 favorite on the money line (risk $132 to win $100) in the latest 2025 MLB All-Star Game odds from DraftKings Sportsbook, with the AL at +108. The total number of runs Vegas thinks will be scored, or the over/under, is 7 in the latest MLB odds. 

Before you make any 2025 MLB All-Star Game picks or MLB predictions, you need to see what SportsLine's Bruce Marshall has to say.

An in-demand guest on numerous sports talk radio and TV shows across the country, Marshall's vast array of editorial work has been featured in the Las Vegas Review-Journal, the New York Post and many other outlets. He has won various handicapping titles and also is working on several book projects. Marshall has crushed his MLB picks this season for SportsLine members.

Bruce Marshall enters the MLB All-Star break as SportsLine's No. 1 expert, returning +1022 on his past 92 MLB picks.

We can tell you Marshall is leaning Under on the run total, and also has found a critical x-factor that makes one side the value pick!

Who wins the 2025 MLB All-Star Game, and what critical X-factor makes one side a must-back? Join SportsLine right now to see which side of the 2025 MLB All-Star Game spread you need to jump on, all from the expert who has returned more than $1,000 for $100 players in his last 293 MLB picks!