2024 Week 6 college football odds, picks, predictions, schedule: Best bets, betting trends, and more from seasoned CFB experts and SportsLine's advanced computer model

The Week 6 college football schedule features just one ranked matchup in No. 9 Missouri vs. No. 25 Texas A&M, but it is loaded with other intriguing conference matchups. The Aggies are 2.5-point home favorites, per the Week 6 college football odds, while Washington is favored by the same line in its matchup with Michigan. Elsewhere in the Big Ten, No. 3 Ohio State is a 20.5-point favorite over Iowa, which is one of the biggest Week 6 college football spreads. Additionally, the first contest for the 2024 Commander-in-Chief's Trophy will take place with Navy vs. Air Force (+10) on Saturday at noon ET.

SportsLine's college football experts and advanced computer model have analyzed the entire Week 6 college football schedule and revealed the top college football picks, college football betting trends, college football best bets, and more. If you're not already a subscriber, join SportsLine here to get everything you need to crush your Week 6 college football picks!