The fifth-seeded Duke Blue Devils continue their quest for a sixth national title when they square off against the No. 4 seed Tennessee Volunteers in a second-round matchup in the East Region of the 2023 NCAA Tournament on Saturday. Duke, which won its last championship in 2015, cruised to a 74-51 victory against Oral Roberts in the first round. Tennessee had a more difficult time in its opener as it edged Louisiana 58-55 on Thursday.

Tip-off at the Amway Center in Orlando, Fla. is scheduled for 2:40 p.m. ET on CBS. The Blue Devils are 3.5-point favorites in the latest Duke vs. Tennessee odds from Caesars Sportsbook, while the over/under for total points scored is 125.5. (See up-to-date odds for every game this week on our college basketball odds page.)

Before making any Tennessee vs. Duke picks, or NCAA Tournament selections, you need to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Div. I college basketball game 10,000 times. The model entered the 2023 NCAA Tournament 79-53 on all-top rated college basketball picks this season, returning nearly $1,300 for $100 players. Anybody who has followed the model has seen HUGE returns!

The model knows Duke is riding a 10-game winning streak, with its last loss coming on Feb. 11 in overtime against Virginia. The Blue Devils exacted revenge with a 59-49 triumph in the ACC Tournament championship game last weekend and rolled past Oral Roberts in coach Jon Scheyer's first NCAA Tournament contest. After setting a career high with 23 points against the Cavaliers, junior guard Jeremy Roach matched it by going 9-for-17 from the field versus the Golden Eagles on Thursday.

But the model also knows Tennessee lost seven of 12 contests before getting past Louisiana on Thursday. Senior guard Tyreke Key led the Volunteers with 12 points off the bench while sophomore guard Jahmai Mashack scored 11 on 4-of-6 shooting. Tennessee came up with a solid defensive performance against the Ragin' Cajuns, limiting them to 40% shooting and forcing 14 turnovers.

Now, the model has set its sights on Duke vs. Tennessee. We can tell you the model is leaning Over on the point total, and it also says one side of the spread hits in almost 60% of simulations! You ABSOLUTELY need to see the model before locking in any college basketball picks.

Who wins Duke vs. Tennessee? And which side of the spread covers almost 60% of the time? ... Join SportsLine right now to find out which side of the Tennessee vs. Duke spread you should be all over Saturday, all from the model on a roll on college basketball picks!