The 15th-ranked Michigan Wolverines battle the USC Trojans in a key Big Ten Conference matchup on Saturday night. Michigan is coming off a 24-10 win over Wisconsin last week, while USC is coming off a 34-32 loss at Illinois on Sept. 27. The Wolverines (4-1, 2-0 Big Ten), who are tied for first in the conference, are 1-1 on the road this season. The Trojans (4-1, 2-1 Big Ten), who are tied for fifth, are 3-0 on their home field in 2025.

Kickoff from Los Angeles Memorial Coliseum is at 7:30 p.m. ET. USC leads the all-time series 6-5. The Trojans are 2.5-point favorites in the latest Michigan vs. USC odds, while the over/under for total points scored is 57.5 via SportsLine consensus. 

Before making any Michigan vs. USC picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 38-25 combined on money-line and over/under picks since the beginning of 2024. Anyone following at sportsbooks and on betting apps could have seen STRONG returns!

The model has simulated Michigan vs. USC 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in over 60% of simulations!

So who wins Michigan vs. USC, and which side of the spread hits over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!