No. 15 Oregon (10-3) and No. 14 Oklahoma (10-2) match up in the 2021 Valero Alamo Bowl on Wednesday night. This battle will take place at the Alamodome in San Antonio, Texas. 

Oklahoma is favored by seven points in the Oregon vs. Oklahoma odds from Caesars Sportsbook, while the Over-Under for total points is set at 64. (See the latest college football lines for all of this week's games on our college football odds page.) Kickoff is set for 9:15 p.m. ET.

Before you consider your Oregon vs. Oklahoma picks or college football predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It also enters the third week of the 2021-22 college football bowl season on a 43-30 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

The model knows Oklahoma freshman quarterback Caleb Williams has shown his playmaking ability since taking over the starting gig. Williams has completed 62 percent of his passes for 1,670 yards with 18 passing touchdowns. The Washington D.C. native has thrown for at least two passing touchdowns in five of his seven starts. 

The model also knows Oregon senior quarterback Anthony Brown is a great dual-threat option for this offense. Brown has completed 64 percent of his passes for 2,683 passing yards with 15 passing touchdowns. He was also second on the team and rushed for 637 yards with nine scores. 

Now, it has set its sights on Oregon vs. Oklahoma. We can tell you the model is leaning under the total and it also says one side of the spread hits in almost 60 percent of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Oregon vs. Oklahoma? And which side of the spread hits in almost 60 percent of simulations? ... Join SportsLine right now to find out which side of Oregon vs. Oklahoma spread you should be all over Wednesday, all from the model on a roll on college football picks!