2021 NCAA Tournament odds, lines: Proven model reveals picks for Monday's Ohio-Creighton matchup

The 13th-seeded Ohio Bobcats (16-7) will try to pull another major upset when they face the No. 5-seeded Creighton Bluejays (21-8) in the second round of the 2021 NCAA Tournament on Monday. Tip-off is set for 6:10 p.m. ET in Indianapolis. William Hill Sportsbook lists the Bluejays as 5.5-point favorites in its latest Ohio vs. Creighton odds, and the Over-Under for total points scored is 149.5 (For the latest college basketball lines for all of today's games, head over to our college basketball odds page). 

Before making any Ohio vs. Creighton picks, you MUST check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of over $2,500 for $100 players on its top-rated college basketball picks against the spread. It has also returned almost $500 on all top-rated college basketball picks this season. Anyone who has followed it has seen HUGE returns.

Now, it has broken down Ohio vs. Creighton, and we can tell you the model is leaning Over the total. It also has generated a spread pick that is hitting in well over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Ohio vs. Creighton? And which side of the spread is hitting in well over 50 percent of simulations? ... Join SportsLine right now to find out which side of the Ohio vs. Creighton spread you should be all over Monday, all from the model up more than $2,500 on its top-rated college basketball picks over the past four seasons!