ANALYSIS: The Chiefs have had the Ravens' number. Since Andy Reid took over as coach, Kansas City is 4-0 against Baltimore, winning by 10.5 points per game. Part of the reason is the Ravens' preference to play man defense; that just doesn't work against the Chiefs receivers, especially Tyreek Hill. I think Hill and Patrick Mahomes have another big game against a Baltimore team playing on a short week.

ANALYSIS: The 49ers are a really good team. Two seasons ago they led the Chiefs entering the fourth quarter of the Super Bowl before losing. Last season they were decimated by injuries, but Nick Bosa, Jimmy Garoppolo & Co. are back. Last week's final score was deceiving; San Francisco was up by 28 on the Lions before pulling the starters, including Bosa. Also, I like that the team stayed on the East Coast after beating Detroit instead of flying back-and-forth for this game. I'm on the Niners to win big.

ANALYSIS: This will be a very tough game for the Raiders after the week they've had: an overtime win on Monday night before flying all the way to the East Coast to play a 1 p.m. ET game in a stadium that will be full for the first time since the 2019 season. I'm not going to overreact to the Raiders beating Baltimore in the first real home game at Allegiant. Steelers win comfortably.

ANALYSIS: The Bills are loaded this season with quarterback Josh Allen and receiver Stefon Diggs and have big goals this season. Meanwhile the Steelers lost four of their last five games last season after starting the season 11-0, and I don't think that they got much better in the offseason. I think Buffalo crushes Pittsburgh.

ANALYSIS: The 49ers made the Super Bowl two seasons ago but struggled last season with injuries and missed the playoffs. They're healthy again, and I think they will get back to their winning ways. I expect the San Francisco defense to give new Lions quarterback Jared Goff fits just like it did when he was with the Rams in the NFC West. 49ers big.