Both teams have been dominant in their two tuneup games leading up to this matchup. Purdue looks better than they were in 2024, but that's not saying much. Meanwhile, the Trojans have been outstanding on both sides of the ball and have far more explosiveness than the Boilermakers. Look for another strong performance from QB Jayden Maiava and a big USC win.

This has moved to -21.5 in a bunch of books, so try to get the -21 while you still can. It's hard to take much from either team's first two games. USC is averaging 66 points through two games but has played Missouri State and Georgia Southern, while Purdue has played Ball State and Southern Illinois. Purdue didn't have an FBS win last season and has a new roster. While they should be improved this season, they were 0-5 SU and ATS in FBS home games last season with an average score of 9-41. Going from Ball State and Southern Illinois to USC is quite the step up in competition, and USC has shown they are explosive on offense. Take USC -21 here.