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NFL schedule 2021: Week 6 picks, odds, predictions, best bets, point spreads, lines, DFS advice, TV coverage

Week 6 NFL picks, best bets, point spreads, expert betting advice and TV coverage for all 14 games
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For the second straight week, favored teams fared as well as the underdogs against the NFL point spreads. In Week 4, it was an even 8-8 split for favorites vs. underdogs, and in Week 5 the ATS favorites came out slightly ahead at 8-7-1. Will that trend continue in Week 6? Or will the underdogs get back to covering point spreads at the rate they had been early in the season? Only time will tell.

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The NFL Week 6 schedule features several intriguing matchups including the Ravens vs. Chargers in a matchup featuring two of the best young quarterbacks (Lamar Jackson and Justin Herbert) in the league leading two of the top contenders in the AFC; the Browns vs. Cardinals in a matchup between two teams that will both likely qualify for the postseason; and a Monday Night Football matchup between the Titans and Bills, which will give NFL fans another look at Buffalo in a prime time slot.  

Here is a full rundown of the NFL Week 6 slate of games and TV schedule, as well as point spreads, betting lines, odds, picks, predictions, and DFS advice for several matchups.

Bye week: 

  • Atlanta Falcons
  • New Orleans Saints
  • New York Jets
  • San Francisco 49ers

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Tampa Bay Buccaneers vs. Philadelphia Eagles

  • Buccaneers vs. Eagles date and time: Thursday, October 14 at 8:20 p.m. ET
  • Buccaneers vs. Eagles spread: Buccaneers -7
  • Buccaneers vs. Eagles over-under: 52.5
  • Buccaneers vs. Eagles moneyline: Buccaneers -300, Eagles +240
  • Buccaneers vs. Eagles TV Coverage: NFL Network

Expert Buccaneers vs. Eagles picks HERE. Thursday Night Football DFS lineup advice HERE.

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Miami Dolphins vs. Jacksonville Jaguars (London)

  • Dolphins vs. Jaguars date and time: Sunday, October 17 at 9:30 a.m. ET from Tottenham Hotspur Stadium in London
  • Dolphins vs. Jaguars spread: Dolphins -3.5
  • Dolphins vs. Jaguars over-under: 47
  • Dolphins vs. Jaguars moneyline: Jaguars +155, Dolphins -180
  • Dolphins vs. Jaguars TV coverage: CBS

Green Bay Packers vs. Chicago Bears

  • Packers vs. Bears date and time: Sunday, October 17 at 1 p.m. ET
  • Packers vs. Bears spread: Packers -4.5
  • Packers vs. Bears over-under: 44.5
  • Packers vs. Bears moneyline: Packers -210, Bears +175
  • Packers vs. Bears TV coverage: Fox

Expert Bears vs. Packers picks HERE.

Cincinnati Bengals vs. Detroit Lions

  • Lions vs. Bengals date and time: Sunday, October 17 at 1 p.m. ET
  • Lions vs. Bengals spread: Bengals -3.5
  • Lions vs. Bengals over-under: 47.5
  • Lions vs. Bengals moneyline: Bengals -210, Lions +155
  • Lions vs. Bengals TV coverage: Fox

Who wins every NFL game? And which teams will sink your bankroll? Join SportsLine now to get NFL picks every week, all from the model that simulates every game 10,000 times and is up almost $8,000.

Houston Texans vs. Indianapolis Colts

  • Texans vs. Colts date and time: Sunday, October 17 at 1 p.m. ET
  • Texans vs. Colts spread: Colts -9.5
  • Texans vs. Colts over-under: 43.5
  • Texans vs. Colts moneyline: Colts -450, Texans +350
  • Texans vs. Colts TV coverage: CBS

Los Angeles Rams vs. New York Giants

  • Rams vs. Giants date and time: Sunday, October 17 at 1 p.m. ET
  • Rams vs. Giants spread: Rams -9.5
  • Rams vs. Giants over-under: 48.5
  • Rams vs. Giants moneyline: Rams -550, Giants +400
  • Rams vs. Giants TV coverage: Fox

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Kansas City Chiefs vs. Washington Football Team

  • Chiefs vs. Washington date and time: Sunday, October 17 at 1 p.m. ET
  • Chiefs vs. Washington spread: Chiefs -7
  • Chiefs vs. Washington over-under: 55.5
  • Chiefs vs. Washington moneyline: Chiefs -330, Washington +260
  • Chiefs vs. Washington TV coverage: CBS

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Carolina Panthers vs. Minnesota Vikings

  • Vikings vs. Panthers date and time: Sunday, October 17 at 1 p.m. ET
  • Vikings vs. Panthers spread: Vikings -1
  • Vikings vs. Panthers over-under: 46
  • Vikings vs. Panthers moneyline: Vikings -120, Panthers +100
  • Vikings vs. Panthers TV coverage: Fox

Which Fantasy Football sleepers, breakouts and busts should you target and fade? And which QB shocks the NFL with a top-five performance? Join SportsLine now to get 2021 Fantasy Football cheat sheets for every single position, all from the model that called Josh Allen's huge season.

Los Angeles Chargers vs. Baltimore Ravens

  • Chargers vs. Ravens date and time: Sunday, October 17 at 1 p.m. ET
  • Chargers vs. Ravens spread: Ravens -3
  • Chargers vs. Ravens over-under: 52
  • Chargers vs. Ravens moneyline: Chargers +140, Ravens -160
  • Chargers vs. Ravens TV coverage: CBS

Arizona Cardinals vs. Cleveland Browns

  • Browns vs. Cardinals date and time: Sunday, October 17 at 4:05 p.m. ET
  • Browns vs. Cardinals spread: Browns -3
  • Browns vs. Cardinals over-under: 49.5
  • Browns vs. Cardinals moneyline: Cardinals +140, Browns -160
  • Browns vs. Cardinals TV coverage: Fox

Who wins every NFL game? And which teams will sink your bankroll? Join SportsLine now to get NFL picks every week, all from the model that simulates every game 10,000 times and is up almost $8,000.

Las Vegas Raiders vs. Denver Broncos

  • Broncos vs. Raiders date and time: Sunday, October 17 at 4:25 p.m. ET
  • Broncos vs. Raiders spread: Broncos -3.5
  • Broncos vs. Raiders over-under: 44
  • Broncos vs. Raiders moneyline: Broncos -190, Raiders +160
  • Broncos vs. Raiders TV coverage: CBS

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Dallas Cowboys vs. New England Patriots

  • Cowboys vs. Patriots date and time: Sunday, October 17 at 4:25 p.m. ET
  • Cowboys vs. Patriots spread: Cowboys -3.5
  • Cowboys vs. Patriots over-under: 51
  • Cowboys vs. Patriots moneyline: Cowboys -190, Patriots +160
  • Cowboys vs. Patriots TV coverage: CBS

Seattle Seahawks vs. Pittsburgh Steelers

  • Steelers vs. Seahawks date and time: Sunday, October 17 at 8:20 p.m. ET
  • Steelers vs. Seahawks spread: Steelers -5
  • Steelers vs. Seahawks over-under: 42.5
  • Steelers vs. Seahawks moneyline: Steelers -230, Seahawks +190
  • Steelers vs. Seahawks TV coverage: NBC

Buffalo Bills vs. Tennessee Titans

  • Bills vs. Titans date and time: Monday, October 18 at 8:15 p.m. ET
  • Bills vs. Titans spread: Bills -5.5
  • Bills vs. Titans over-under: 54
  • Bills vs. Titans moneyline: Bills -250, Titans +205
  • Bills vs. Titans TV coverage: ESPN

Which Fantasy Football sleepers, breakouts and busts should you target and fade? And which QB shocks the NFL with a top-five performance? Join SportsLine now to get 2021 Fantasy Football cheat sheets for every single position, all from the model that called Josh Allen's huge season.

SportsLine Staff