NFL schedule 2021: Week 6 picks, odds, predictions, best bets, point spreads, lines, DFS advice, TV coverage
Week 6 NFL picks, best bets, point spreads, expert betting advice and TV coverage for all 14 games


For the second straight week, favored teams fared as well as the underdogs against the NFL point spreads. In Week 4, it was an even 8-8 split for favorites vs. underdogs, and in Week 5 the ATS favorites came out slightly ahead at 8-7-1. Will that trend continue in Week 6? Or will the underdogs get back to covering point spreads at the rate they had been early in the season? Only time will tell.
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The NFL Week 6 schedule features several intriguing matchups including the Ravens vs. Chargers in a matchup featuring two of the best young quarterbacks (Lamar Jackson and Justin Herbert) in the league leading two of the top contenders in the AFC; the Browns vs. Cardinals in a matchup between two teams that will both likely qualify for the postseason; and a Monday Night Football matchup between the Titans and Bills, which will give NFL fans another look at Buffalo in a prime time slot.
Here is a full rundown of the NFL Week 6 slate of games and TV schedule, as well as point spreads, betting lines, odds, picks, predictions, and DFS advice for several matchups.
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Expert Buccaneers vs. Eagles picks HERE. Thursday Night Football DFS lineup advice HERE.
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Expert Bears vs. Packers picks HERE.
Who wins every NFL game? And which teams will sink your bankroll? Join SportsLine now to get NFL picks every week, all from the model that simulates every game 10,000 times and is up almost $8,000.
Looking for expert advice to sharpen your betting skills? Or do you need an edge in your fantasy league? Sign up for the SportsLine Daily newsletter NOW to get sports picks and fantasy advice delivered directly to your inbox.
Looking for expert advice to sharpen your betting skills? Or do you need an edge in your fantasy league? Sign up for the SportsLine Daily newsletter NOW to get sports picks and fantasy advice delivered directly to your inbox.
Which Fantasy Football sleepers, breakouts and busts should you target and fade? And which QB shocks the NFL with a top-five performance? Join SportsLine now to get 2021 Fantasy Football cheat sheets for every single position, all from the model that called Josh Allen's huge season.
Who wins every NFL game? And which teams will sink your bankroll? Join SportsLine now to get NFL picks every week, all from the model that simulates every game 10,000 times and is up almost $8,000.
Looking for expert advice to sharpen your betting skills? Or do you need an edge in your fantasy league? Sign up for the SportsLine Daily newsletter NOW to get sports picks and fantasy advice delivered directly to your inbox.
Which Fantasy Football sleepers, breakouts and busts should you target and fade? And which QB shocks the NFL with a top-five performance? Join SportsLine now to get 2021 Fantasy Football cheat sheets for every single position, all from the model that called Josh Allen's huge season.