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NFL schedule 2021: Week 5 picks, odds, predictions, best bets, spreads, DFS plays, TV coverage for all games

Week 5 NFL picks, best bets, point spreads, expert betting advice and TV coverage for all 16 games
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The first month of the 2021 NFL season is in the books, and as expected the action lived up to the hype. After four weeks, only one team remains undefeated -- the Arizona Cardinals; several surprising teams have emerged as top Super Bowl 56 contenders -- the Dallas Cowboys, Cleveland Browns, Los Angeles Chargers, and the Cardinals; and the race for the No. 1 overall pick in the 2022 NFL Draft is officially on, with the Detroit Lions and Jacksonville Jaguars leading the way.

Against the spread favorites 8-8 in Week 4, marking the first time ATS underdogs haven't prevailed in the weekly standings in 2021. Will Week 5 be the week the favorites finally come out ahead? Or will the underdogs continue to cover spreads at an eye-opening rate? Only time will tell.

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The NFL Week 5 schedule features a bevy of intriguing matchups including the Rams vs. Seahawks on Thursday Night Football in a matchup between two NFC East teams with championship aspirations; the Browns vs. Chargers in a battle between two surprising contenders in the AFC; the 49ers vs. Cardinals in a critical NFC West tilt featuring MVP front-runner Kyler Murray; and a Sunday Night Football matchup between the Chiefs and Bills, which will serve as a rematch of last year's AFC Championship Game.  

Here is a full rundown of the NFL Week 5 slate of games and TV schedule, as well as odds, picks, and predictions for several matchups.

Who wins every NFL game? And which teams will sink your bankroll? Join SportsLine now to get NFL picks every week, all from the model that simulates every game 10,000 times and is up almost $8,000. 

Los Angeles Rams vs. Seattle Seahawks

  • Rams vs. Seahawks date and time: Thursday, October 7 at 8:20 p.m. ET
  • Rams vs. Seahawks spread: Rams -2
  • Rams vs. Seahawks over-under: 54.5
  • Rams vs. Seahawks moneyline: Seahawks +115, Rams -135
  • Rams vs. Seahawks TV Coverage: NFL Network

Expert Seahawks vs. Rams picks HERE. Expert Rams vs. Seahawks DFS lineup advice HERE.

New York Jets vs. Atlanta Falcons (London)

  • Falcons vs. Jets date and time: Sunday, October 10 at 9:30 a.m. ET from Tottenham Hotspur Stadium in London
  • Falcons vs. Jets spread: Falcons -3
  • Falcons vs. Jets over-under: 46
  • Falcons vs. Jets moneyline: Jets +140, Falcons -160
  • Falcons vs. Jets TV coverage: NFL Network

Green Bay Packers vs. Cincinnati Bengals

  • Packers vs. Bengals date and time: Sunday, October 10 at 1 p.m. ET
  • Packers vs. Bengals spread: Packers -3
  • Packers vs. Bengals over-under: 50.5
  • Packers vs. Bengals moneyline: Packers -160, Bengals +140
  • Packers vs. Bengals TV coverage: Fox

Detroit Lions vs. Minnesota Vikings

  • Lions vs. Vikings date and time: Sunday, October 10 at 1 p.m. ET
  • Lions vs. Vikings spread: Vikings -7.5
  • Lions vs. Vikings over-under: 49
  • Lions vs. Vikings moneyline: Vikings -350, Lions +280
  • Lions vs. Vikings TV coverage: Fox

Who wins every NFL game? And which teams will sink your bankroll? Join SportsLine now to get NFL picks every week, all from the model that simulates every game 10,000 times and is up almost $8,000.

Denver Broncos vs. Pittsburgh Steelers

  • Broncos vs. Steelers date and time: Sunday, October 10 at 1 p.m. ET
  • Broncos vs. Steelers spread: Steelers -1
  • Broncos vs. Steelers over-under: 40
  • Broncos vs. Steelers moneyline: Broncos -105, Steelers -115
  • Broncos vs. Steelers TV coverage: Fox

Expert Steelers vs. Broncos player prop bet picks HERE.

Tampa Bay Buccaneers vs. Miami Dolphins

  • Buccaneers vs. Dolphins date and time: Sunday, October 10 at 1 p.m. ET
  • Buccaneers vs. Dolphins spread: Buccaneers -10
  • Buccaneers vs. Dolphins over-under: 48
  • Buccaneers vs. Dolphins moneyline: Dolphins +360, Buccaneers -475
  • Buccaneers vs. Dolphins TV coverage: CBS

New Orleans Saints vs. Washington Football Team

  • Saints vs. Washington date and time: Sunday, October 10 at 1 p.m. ET
  • Saints vs. Washington spread: Saints -1.5
  • Saints vs. Washington over-under: 44.5
  • Saints vs. Washington moneyline: Saints -130, Washington +110
  • Saints vs. Washington TV coverage: CBS

Expert Saints vs. Washington player prop bet picks HERE.

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Philadelphia Eagles vs. Carolina Panthers

  • Eagles vs. Panthers date and time: Sunday, October 10 at 1 p.m. ET
  • Eagles vs. Panthers spread: Panthers -4
  • Eagles vs. Panthers over-under: 45
  • Eagles vs. Panthers moneyline: Eagles +160 Panthers -190
  • Eagles vs. Panthers TV coverage: Fox

Which Fantasy Football sleepers, breakouts and busts should you target and fade? And which QB shocks the NFL with a top-five performance? Join SportsLine now to get 2021 Fantasy Football cheat sheets for every single position, all from the model that called Josh Allen's huge season.

Tennessee Titans vs. Jacksonville Jaguars

  • Titans vs. Jaguars date and time: Sunday, October 10 at 1 p.m. ET
  • Titans vs. Jaguars spread: Titans -4
  • Titans vs. Jaguars over-under: 48.5
  • Titans vs. Jaguars moneyline: Titans -200, Jaguars +170
  • Titans vs. Jaguars TV coverage: CBS

Expert Jaguars vs. Titans picks HERE.

New England Patriots vs. Houston Texans

  • Patriots vs. Texans date and time: Sunday, October 10 at 1 p.m. ET
  • Patriots vs. Texans spread: Patriots -9
  • Patriots vs. Texans over-under: 39.5
  • Patriots vs. Texans moneyline: Texans +330, Patriots -430
  • Patriots vs. Texans TV coverage: CBS

Chicago Bears vs. Las Vegas Raiders

  • Bears vs. Raiders date and time: Sunday, October 10 at 4:05 p.m. ET
  • Bears vs. Raiders spread: Raiders -5.5
  • Bears vs. Raiders over-under: 44.5
  • Bears vs. Raiders moneyline: Bears +200, Raiders -240
  • Bears vs. Raiders TV coverage: CBS

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Cleveland Browns vs. Los Angeles Chargers

  • Browns vs. Chargers date and time: Sunday, October 10 at 4:05 p.m. ET
  • Browns vs. Chargers spread: Chargers -1.5
  • Browns vs. Chargers over-under: 48.5
  • Browns vs. Chargers moneyline: Browns +105, Chargers -125
  • Browns vs. Chargers TV coverage: CBS

Expert Chargers vs. Browns picks HERE.

Who wins every NFL game? And which teams will sink your bankroll? Join SportsLine now to get NFL picks every week, all from the model that simulates every game 10,000 times and is up almost $8,000.

Arizona Cardinals vs. San Francisco 49ers

  • Cardinals vs. 49ers date and time: Sunday, October 10 at 4:25 p.m. ET
  • Cardinals vs. 49ers spread: Cardinals -5.5
  • Cardinals vs. 49ers over-under: 50
  • Cardinals vs. 49ers moneyline: Cardinals -250, 49ers +205
  • Cardinals vs. 49ers TV coverage: Fox

Expert 49ers vs. Cardinals picks HERE.

New York Giants vs. Dallas Cowboys

  • Giants vs. Cowboys date and time: Sunday, October 10 at 4:25 p.m. ET
  • Giants vs. Cowboys spread: Cowboys -7
  • Giants vs. Cowboys over-under: 52
  • Giants vs. Cowboys moneyline: Giants +260, Cowboys -330
  • Giants vs. Cowboys TV coverage: Fox

Expert Cowboys vs. Giants picks HERE.

Buffalo Bills vs. Kansas City Chiefs

  • Bills vs. Chiefs date and time: Sunday, October 10 at 8:20 p.m. ET
  • Bills vs. Chiefs spread: Chiefs -2.5
  • Bills vs. Chiefs over-under: 56.5
  • Bills vs. Chiefs moneyline: Bills +130, Chiefs -150
  • Bills vs. Chiefs TV coverage: NBC

Expert Chiefs vs. Bills picks HERE.

Indianapolis Colts vs. Baltimore Ravens

  • Colts vs. Ravens date and time: Monday, October 11 at 8:15 p.m. ET
  • Colts vs. Ravens spread: Ravens -7
  • Colts vs. Ravens over-under: 46
  • Colts vs. Ravens moneyline: Colts +260, Ravens -330
  • Colts vs. Ravens TV coverage: ESPN

Which Fantasy Football sleepers, breakouts and busts should you target and fade? And which QB shocks the NFL with a top-five performance? Join SportsLine now to get 2021 Fantasy Football cheat sheets for every single position, all from the model that called Josh Allen's huge season.

SportsLine Staff