NFL schedule 2021: Week 5 picks, odds, predictions, best bets, spreads, DFS plays, TV coverage for all games
Week 5 NFL picks, best bets, point spreads, expert betting advice and TV coverage for all 16 games
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The first month of the 2021 NFL season is in the books, and as expected the action lived up to the hype. After four weeks, only one team remains undefeated -- the Arizona Cardinals; several surprising teams have emerged as top Super Bowl 56 contenders -- the Dallas Cowboys, Cleveland Browns, Los Angeles Chargers, and the Cardinals; and the race for the No. 1 overall pick in the 2022 NFL Draft is officially on, with the Detroit Lions and Jacksonville Jaguars leading the way.
Against the spread favorites 8-8 in Week 4, marking the first time ATS underdogs haven't prevailed in the weekly standings in 2021. Will Week 5 be the week the favorites finally come out ahead? Or will the underdogs continue to cover spreads at an eye-opening rate? Only time will tell.
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The NFL Week 5 schedule features a bevy of intriguing matchups including the Rams vs. Seahawks on Thursday Night Football in a matchup between two NFC East teams with championship aspirations; the Browns vs. Chargers in a battle between two surprising contenders in the AFC; the 49ers vs. Cardinals in a critical NFC West tilt featuring MVP front-runner Kyler Murray; and a Sunday Night Football matchup between the Chiefs and Bills, which will serve as a rematch of last year's AFC Championship Game.
Here is a full rundown of the NFL Week 5 slate of games and TV schedule, as well as odds, picks, and predictions for several matchups.
Who wins every NFL game? And which teams will sink your bankroll? Join SportsLine now to get NFL picks every week, all from the model that simulates every game 10,000 times and is up almost $8,000.
Expert Seahawks vs. Rams picks HERE. Expert Rams vs. Seahawks DFS lineup advice HERE.
Who wins every NFL game? And which teams will sink your bankroll? Join SportsLine now to get NFL picks every week, all from the model that simulates every game 10,000 times and is up almost $8,000.
Expert Steelers vs. Broncos player prop bet picks HERE.
Expert Saints vs. Washington player prop bet picks HERE.
Looking for expert advice to sharpen your betting skills? Or do you need an edge in your fantasy league? Sign up for the SportsLine Daily newsletter NOW to get sports picks and fantasy advice delivered directly to your inbox.
Which Fantasy Football sleepers, breakouts and busts should you target and fade? And which QB shocks the NFL with a top-five performance? Join SportsLine now to get 2021 Fantasy Football cheat sheets for every single position, all from the model that called Josh Allen's huge season.
Expert Jaguars vs. Titans picks HERE.
Looking for expert advice to sharpen your betting skills? Or do you need an edge in your fantasy league? Sign up for the SportsLine Daily newsletter NOW to get sports picks and fantasy advice delivered directly to your inbox.
Expert Chargers vs. Browns picks HERE.
Who wins every NFL game? And which teams will sink your bankroll? Join SportsLine now to get NFL picks every week, all from the model that simulates every game 10,000 times and is up almost $8,000.
Expert 49ers vs. Cardinals picks HERE.
Expert Cowboys vs. Giants picks HERE.
Expert Chiefs vs. Bills picks HERE.
Which Fantasy Football sleepers, breakouts and busts should you target and fade? And which QB shocks the NFL with a top-five performance? Join SportsLine now to get 2021 Fantasy Football cheat sheets for every single position, all from the model that called Josh Allen's huge season.