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NFL schedule 2021: Odds, picks, predictions, best bets, lines, TV coverage for full slate of Week 1 games

Odds, picks, best bets, and TV coverage for every game on the 2021 NFL Week 1 schedule
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It seems hard to believe, but it's been over six months since the Tampa Bay Buccaneers defeated the Kansas City Chiefs in Super Bowl LV. Tom Brady and the Buccaneers will begin their Super Bowl title defense on Thursday, September 9 when they take on Dak Prescott and the Dallas Cowboys in the first game of the 2021 NFL schedule. 

Week 1 features a full slate of games with several intriguing matchups including Steelers vs. Bills, where fans will get a look at top NFL MVP candidate Josh Allen taking on one of the league's best defenses; the Browns vs. Chiefs, which will feature Patrick Mahomes, Baker Mayfield, and several other Pro Bowl caliber players; and Bears vs. Rams on Sunday Night Football, where fans will get their first look at Matthew Stafford in a Rams uniform.

Here is a full rundown of the NFL Week 1 slate of games and TV schedule, as well as odds, picks, and predictions for several matchups. 

Which Fantasy Football sleepers, breakouts and busts should you target and fade? And which QB shocks the NFL with a top-five performance? Join SportsLine now to get 2021 Fantasy Football cheat sheets for every single position, all from the model that called Josh Allen's huge season.

Dallas Cowboys vs. New England Patriots

  • Cowboys vs. Buccaneers date and time: Thursday, September 9 at 8:20 p.m. ET
  • Cowboys vs. Buccaneers spread: Buccaneers -7.5
  • Cowboys vs. Buccaneers over-under: 51.5
  • Cowboys vs. Buccaneers moneyline: Cowboys +300, Patriots -380
  • Cowboys vs. Buccaneers TV Coverage: NBC

Expert Cowboys vs. Buccaneers picks HERE.

Philadelphia Eagles vs. Atlanta Falcons

  • Eagles vs. Falcons date and time: Sunday, September 12 at 1 p.m. ET
  • Eagles vs. Falcons spread: Falcons -3.5
  • Eagles vs. Falcons over-under: 48
  • Eagles vs. Falcons moneyline: Falcons -180, Eagles +155
  • Eagles vs. Falcons TV coverage: Fox

Pittsburgh Steelers vs. Buffalo Bills

  • Steelers vs. Bills date and time: Sunday, September 12 at 1 p.m. ET
  • Steelers vs. Bills spread: Bills -6.5
  • Steelers vs. Bills over-under: 48.5
  • Steelers vs. Bills moneyline: Bills -290, Steelers +235
  • Steelers vs. Bills TV coverage: CBS

Minnesota Vikings vs. Cincinnati Bengals

  • Vikings vs. Bengals date and time: Sunday, September 12 at 1 p.m. ET
  • Vikings vs. Bengals spread: Vikings -3
  • Vikings vs. Bengals over-under: 48
  • Vikings vs. Bengals moneyline: Vikings -190, Bengals +160
  • Vikings vs. Bengals TV coverage: Fox

Who wins every NFL game? And which teams will sink your bankroll? Join SportsLine now to get NFL picks every week, all from the model that simulates every game 10,000 times and is up almost $8,000.

San Francisco 49ers vs. Detroit Lions

  • 49ers vs. Lions date and time: Sunday, September 12 at 1 p.m. ET
  • 49ers vs. Lions spread: 49ers -7.5
  • 49ers vs. Lions over-under: 45.5
  • 49ers vs. Lions moneyline: 49ers -360, Lions +285
  • 49ers vs. Lions TV coverage: Fox

Arizona Cardinals vs. Tennessee Titans

  • Cardinals vs. Titans date and time: Sunday, September 12 at 1 p.m. ET
  • Cardinals vs. Titans spread: Titans -3
  • Cardinals vs. Titans over-under: 52
  • Cardinals vs. Titans moneyline: Cardinals +140, Titans -160
  • Cardinals vs. Titans TV coverage: CBS

Seattle Seahawks vs. Indianapolis Colts

  • Seahawks vs. Colts date and time: Sunday, September 12 at 1 p.m. ET
  • Seahawks vs. Colts spread: Seahawks -2.5
  • Seahawks vs. Colts over-under: 48.5
  • Seahawks vs. Colts moneyline: Seahawks -145, Colts +125
  • Seahawks vs. Colts TV coverage: Fox

Los Angeles Chargers vs. Washington Football Team

  • Chargers vs. Washington date and time: Sunday, September 12 at 1 p.m. ET
  • Chargers vs. Washington spread: Chargers -1
  • Chargers vs. Washington over-under: 44.5
  • Chargers vs. Washington moneyline: Chargers -120, Washington +100
  • Chargers vs. Washington TV coverage: CBS

Which Fantasy Football sleepers, breakouts and busts should you target and fade? And which QB shocks the NFL with a top-five performance? Join SportsLine now to get 2021 Fantasy Football cheat sheets for every single position, all from the model that called Josh Allen's huge season.

New York Jets vs. Carolina Panthers

  • Jets vs. Panthers date and time: Sunday, September 12 at 1 p.m. ET
  • Jets vs. Panthers spread: Panthers -5
  • Jets vs. Panthers over-under: 44.5
  • Jets vs. Panthers moneyline: Jets +190, Panthers -230
  • Jets vs. Panthers TV coverage: CBS

Jacksonville Jaguars vs. Houston Texans

  • Jaguars vs. Texans date and time: Sunday, September 12 at 1 p.m. ET
  • Jaguars vs. Texans spread: Jaguars -3
  • Jaguars vs. Texans over-under: 44.5
  • Jaguars vs. Texans moneyline: Texans +130, Jaguars -150
  • Jaguars vs. Texans TV coverage: CBS

Cleveland Browns vs. Kansas City Chiefs

  • Browns vs. Chiefs date and time: Sunday, September 12 at 4:25 p.m. ET
  • Browns vs. Chiefs spread: Chiefs -6
  • Browns vs. Chiefs over-under: 53
  • Browns vs. Chiefs moneyline: Browns +220, Chiefs -270
  • Browns vs. Chiefs TV coverage: CBS

Miami Dolphins vs. New England Patriots

  • Dolphins vs. Patriots date and time: Sunday, September 12 at 4:25 p.m. ET
  • Dolphins vs. Patriots spread: Patriots -2.5
  • Dolphins vs. Patriots over-under: 44
  • Dolphins vs. Patriots moneyline: Dolphins +130, Patriots -150
  • Dolphins vs. Patriots TV coverage: CBS

Green Bay Packers vs. New Orleans Saints

  • Packers vs. Saints date and time: Sunday, September 12 at 4:25 p.m. ET
  • Packers vs. Saints spread: Packers -4
  • Packers vs. Saints over-under: 50
  • Packers vs. Saints moneyline: Packers -210, Saints +175
  • Packers vs. Saints TV coverage: Fox

Denver Broncos vs. New York Giants

  • Broncos vs. Giants date and time: Sunday, September 12 at 4:25 p.m. ET
  • Broncos vs. Giants spread: Broncos -2.5
  • Broncos vs. Giants over-under: 42.5
  • Broncos vs. Giants moneyline: Giants +130, Broncos -150
  • Broncos vs. Giants TV coverage: Fox

Chicago Bears vs. Los Angeles Rams

  • Bears vs. Rams date and time: Sunday, September 12 at 8:20 p.m. ET
  • Bears vs. Rams spread: Rams -7.5
  • Bears vs. Rams over-under: 44.5
  • Bears vs. Rams moneyline: Bears +285, Rams -360
  • Bears vs. Rams TV coverage: NBC

Baltimore Ravens vs. Las Vegas Raiders

  • Ravens vs. Raiders date and time: Monday, September 13 at 8:15 p.m. ET
  • Ravens vs. Raiders spread: Ravens -4.5
  • Ravens vs. Raiders over-under: 51
  • Ravens vs. Raiders moneyline: Ravens -220, Raiders +180
  • Ravens vs. Raiders TV coverage: ESPN

Which Fantasy Football sleepers, breakouts and busts should you target and fade? And which QB shocks the NFL with a top-five performance? Join SportsLine now to get 2021 Fantasy Football cheat sheets for every single position, all from the model that called Josh Allen's huge season.

SportsLine Staff