Content on this page may include affiliate links. If you click and sign up/place a wager, we may receive compensation at no cost to you.
Three teams remain unbeaten on the year as the NFL schedule enters Week 6. Minnesota at 5-0 will remain that way as it is in its bye week. The other unbeatens are in action when the 4-0 Kansas City Chiefs take on the winless Los Angeles Chargers (-8.5) in an AFC West matchup, and the 5-0 San Francisco 49ers battle the Washington Commanders (-7.5) on Monday Night Football. Claim the latest Polymarket promo code SPORTSLINE to get a $25 trading bonus after a $10 deposit:
There are a number of intriguing matchups in Week 6, including Bears vs. Falcons (+3.5) and Steelers vs. Buccaneers (+3). Other top games include Cowboys vs. Packers (-1.5) on 'Sunday Night Football.' There was hope for Green Bay pass rusher and former Cowboy Micah Parsons (knee) making his return to the lineup, but that does not appear to be likely.
Before locking in any NFL parlays for this slate, make sure you see what SportsLine's advanced computer model has to say.
The model, which simulates every NFL game 10,000 times, is up more than $5,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 6 of the 2026 NFL season on a 57-46 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!
The model has scoured the Week 6 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you'd be looking at a massive payout of over 26-1!
One pick from the model: The model backs the Packers (-113) to win over the Cowboys as Green Bay wins in 65% of simulations.
The model is also backing another over/under pick that hits well over 60% of the time! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!
So which NFL teams should you back in Week 6, and which five picks should you lock in RIGHT NOW? ... Join SportsLine now to see the top parlay picks for this week, all from the model on a 57-46 roll on top-rated NFL picks!
Don't miss out: All new SportsLine memberships include Paramount+ Premium -- a $13.99/month value -- for no extra cost! Join now and get it all.
GET VEGAS EXPERT PICKS FOR NFL, MLB, NBA, CBB, GOLF, NHL, HORSE RACING AND MORE - PLUS ADVANCED COMPUTER SIMULATIONS, WINNING TOOLS, AND MORE!
Written by Daniel Kohn
View expert profile
