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In a possible Super Bowl preview, the Buffalo Bills clash with the Los Angeles Rams on Monday Night Football. Buffalo is coming off a 29-26 loss to the New England Patriots in Week 4, while Los Angeles defeated the Philadelphia Eagles 24-20. The Bills (3-1), who lead the AFC East, are 1-0 on the road this season. The Rams (2-2), who are third in the NFC West, are just 1-1 as the home team in 2026. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
Kickoff is set for 8:15 p.m. ET from SoFi Stadium in Inglewood, Calif. The latest Bills vs. Rams odds have Los Angeles as a 3.5-point favorites. The over/under for total points scored is 55.5.
Before making any Bills vs. Rams picks or 2026 NFL Week 5 predictions, you NEED to see which side the proven SportsLine projection model is on.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 5 of the 2026 NFL season on a 55-44 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!
Now, the model has locked in another confident pick for Bills vs. Rams in the NFL Week 5 2026 matchup.
We can tell you it's leaning Under the point total. It also says that one side of the spread hits in well over 50% of simulations! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.
So who wins Bills vs. Rams in the 2026 Week 5 matchup, and which side of the spread hits well over 50% of the time? ... Join SportsLine RIGHT NOW to see which side of the Bills vs. Rams line to back, all from the model that is on a 55-44 run on top-rated picks since 2024!
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Written by Daniel Kohn
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