Simulation Picks
SPREAD
SF @ CHI
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MONEYLINE
SF @ CHI
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OVER / UNDER
SF @ CHI
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PUBLIC
MONEY
PUBLIC
MONEY
Over0%
PUBLIC
Under0%
Over
MONEY
Under
Understanding Public and Money
Think of 'Public' as the percentage of people betting on each side and 'Money' as how much money is being bet. When there's a big difference between the 'Public' and 'Money' data, it usually means that the more serious bettors (referred to as 'Sharp Money') are favoring a particular side.
Expert Picks
Expert's PickSan Francisco -6.5 -110
LOSS
Unit1.0
+1249.5
64-48-5 in Last 117 NFL Sides Picks
+460
10-5 in Last 15 NFL ATS Picks
Josh's Analysis:
There's a window of value on the 49ers at this reduced number. Trey Lance remains a question mark at QB, but he has some reliable help with the likes of Deebo Samuel and Elijah Mitchell. Justin Fields of Chicago isn't much more proven and he will struggle to throw downfield against the 49ers' pass rush. The Chicago defense will be serviceable but will miss centerpice Khalil Mack, who is now with the Chargers. Look for the 49ers to pull away late and clip this number.
Pick Made: Sep 11, 3:16 pm UTC on WHNJ
Team Injuries
San Francisco 49ers
Wednesday, May 21, 2025

WR
Brandon Aiyuk
Knee - ACL + MCLQuestionable

LB
Nick Martin
Lower Body
Tuesday, May 20, 2025

OT
Colton McKivitz
UndisclosedQuestionable
Sunday, May 18, 2025

DE
Robert Beal Jr.
AnkleQuestionable
Wednesday, May 07, 2025

QB
Kurtis Rourke
KneeQuestionable
Thursday, May 01, 2025

OT
Trent Williams
AnkleQuestionable

P
Mitch Wishnowsky
BackQuestionable

CB
Deommodore Lenoir
ShoulderQuestionable

CB
Tre Brown
KneeQuestionable

SAF
George Odum
KneeQuestionable

OT
Spencer Burford
CalfQuestionable

RB
Isaac Guerendo
Knee - MCLQuestionable

CB
Renardo Green
GroinQuestionable

CB
Darrell Luter Jr.
PelvisQuestionable
Wednesday, Apr 30, 2025

SAF
Malik Mustapha
Knee - ACLQuestionable
Saturday, Feb 22, 2025

DT
Kevin Givens
PectoralQuestionable
Chicago Bears
Wednesday, May 21, 2025

DE
Xavier Carlton
Pro Draft Prep

WR
Luther Burden III
UndisclosedQuestionable
Wednesday, May 07, 2025

DT
Shemar Turner
LegQuestionable

TE
Colston Loveland
ShoulderQuestionable
Wednesday, Apr 30, 2025

DT
Andrew Billings
PectoralQuestionable

OT
Ryan Bates
ConcussionQuestionable

SAF
Elijah Hicks
AnkleQuestionable

CB
Jaylon Johnson
QuadricepsQuestionable

OT
Braxton Jones
AnkleQuestionable

SAF
Jaquan Brisker
ConcussionQuestionable

RB
Ian Wheeler
KneeQuestionable

QB
Caleb Williams
WristQuestionable