The 49ers placed Okuayinonu (foot) on injured reserve Friday.
Smith didn't make an appearance during the Eagles' three-game preseason slate.
Okuayinonu (foot) will not travel with the team to Melbourne, Australia ahead of the Week 1 game versus the Rams, Nick Wagoner of ESPN.com reports.
Bigsby played 10 offensive snaps this preseason before being rested for the final two exhibition contests.
Goedert didn't see any action during the Eagles' three-game preseason slate.
Barkley didn't see any action during the Eagles' three-game preseason slate.
Juszczyk (finger) was a full participant in Wednesday's practice, Nick Wagoner of ESPN.com reports.
Bosa (knee) is making the trip to Australia and still could have a chance to play in the 49ers' Week 1 matchup against the Rams in Melbourne, Ian Rapoport of ESPN and NFL Network reports.
Evans (groin) returned to Wednesday, Nick Wagoner of ESPN.com reports.
Kittle (Achilles) will travel to Australia with the 49ers and "is trending in the right direction to play" in the season opener Sept. 10 versus the Rams, Ian Rapoport of NFL Network reports.
