Perkins (3-12) took the loss against the Guardians on Sunday, allowing one run on five hits and no walks with four strikeouts over six innings.
Lowder (6-12) took the loss Sunday against the Cubs, allowing five runs on six hits and three walks across three innings. He struck out three.
Cortes is absent from the lineup for Sunday's matchup with the Guardians.
Cincinnati promoted Spiers from Triple-A Louisville on Sunday.
Cincinnati designated Friedl for assignment Sunday.
The Reds placed Burns on the 15-day injured list Sunday due to a right groin strain.
Walton went 3-for-3 with a home run, four RBI and a stolen base in Saturdays' 12-6 loss to the Guardians.
Burns didn't factor into the decision in Friday's 6-4 win over the Cubs, giving up two runs on four hits and two walks over three innings. He struck out four.
Pagan walked one and struck out one in a scoreless ninth inning Friday to record his 24th save of the season in a 6-4 win over the Cubs.
De La Cruz went 2-for-2 with two walks, a stolen base and two runs scored in Friday's 6-4 win over the Cubs.
