Yankees vs. Red Sox odds, lines: Advanced computer model releases picks for 2022 MLB season opener for AL East rivals

The New York Yankees look to avenge their loss in last year's American League Wild Card matchup when they host the rival Boston Red Sox in the 2022 MLB season opener for both clubs on Friday, one day after their scheduled contest was postponed due to inclement weather. First pitch from Yankee Stadium is scheduled for 1:05 p.m. ET. 

New York is listed as a -175 favorite (risk $170 to win $100) on the money line in the latest Yankees vs. Red Sox odds from Caesars Sportsbook, while the over-under for total runs scored is eight (see the latest lines for every game on our MLB odds page).

Before making any Red Sox vs. Yankees picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

This model, which simulates every game 10,000 times, enters the 2022 MLB season coming off a 209-178 record on top-rated MLB money-line picks in 2021, returning over $700 for $100 players. Anyone following it has seen HUGE returns!

The model knows New York is counting on Gerrit Cole to have a better outing than he did against Boston in last year's wild-card game, as he surrendered three runs on four hits and two walks in two-plus innings. The 31-year-old right-hander's first full season with the Yankees was a strong one as he led the AL with 16 wins, finished second with 243 strikeouts and was third with a 3.23 ERA. Slugger Giancarlo Stanton performed well against the Red Sox in 2021, registering four home runs and 14 RBIs in 19 games.

The model also knows Boston righty Nathan Eovaldi was superb against his former team in the wild-card matchup, allowing one run and four hits with eight strikeouts in 5 1/3 innings. The 32-year-old faced the Yankees six times during the 2021 regular season and went 2-2 with a 3.71 ERA, allowing only four earned runs over 16 frames in three outings at Yankee Stadium. Boston was fourth in the AL with 829 runs scored last year and hopes for another big offensive season with the addition of Trevor Story, who has scored over 100 runs and driven in at least 72 in each of his five full major-league seasons.

Now, it has set its sights on Yankees vs. Red Sox. We can tell you the model is projecting 9.6 total runs, and it also says one side of the money line has all the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins Yankees vs. Red Sox? And which side of the money line has all the value? ... Join SportsLine right now to find out which side of the Red Sox vs. Yankees money line you should be all over on Friday, all from the model that went 209-178 on top-rated MLB money-line picks in 2021!