The New York Yankees look to complete a three-game sweep when they host the Oakland Athletics in the series finale on Wednesday afternoon. New York (55-20) posted its major league-leading 23rd comeback victory in the opener, a 9-5 triumph, before edging Oakland 2-1 on Tuesday. The Athletics (25-51) have lost 24 of their last 30 contests. First pitch at Yankee Stadium is set for 1:05 p.m. ET.

New York is listed as a -300 favorite (risk $300 to win $100) on the money line in the latest Yankees vs. Athletics odds from Caesars Sportsbook, while the over/under for total runs scored is 8.5 (see the latest lines for every game on our MLB odds page).

Before making any Athletics vs. Yankees picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times and is off to a strong start to the 2022 season. It's on a 59-51 run on top-rated MLB money-line picks through 12 weeks. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

The model knows New York owns the best record in the majors and a 12 1/2-game lead in the American League East. The team has won three straight since being a victim of a no-hitter against Houston on Saturday. Right-hander Jameson Taillon flirted with a no-hitter of his own earlier this month when he was perfect through seven innings against the Los Angeles Angels on June 2 before yielding a leadoff double in the eighth. The 30-year-old hasn't lost since his season debut versus Toronto on Apr. 11 but is coming off his worst outing of the year, a no-decision against Houston on Thursday in which he was tagged for six runs and 10 hits over 5 2/3 innings.

The model also knows Oakland left-hander Cole Irvin will be facing the Yankees for the first time in his career. The 28-year-old has pitched much better this season than his 2-5 record indicates as he's allowed three runs or fewer in 10 of his 12 starts. Irvin has gone 0-4 over eight outings since picking up the victory against Texas on Apr. 24 but has actually lowered his ERA from 3.32 to 3.29 in that span.

Now, it has set its sights on Yankees vs. Athletics. We can tell you the model is projecting 7.8 total runs, and it also says one side of the run line has all the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins Athletics vs. Yankees? And which side of the run line has all the value? ... Join SportsLine right now to find out which side of the Yankees vs. Athletics run line you should be all over on Wednesday, all from the model on a roll on MLB picks!