Xavier vs. Creighton odds, line, spread: Proven model reveals college basketball picks, predictions for Jan. 15, 2022

A Big East battle is on tap between the No. 17 Xavier Musketeers and the Creighton Bluejays at noon ET Saturday at Cintas Center. The Musketeers are 12-3 overall and 9-1 at home, while Creighton is 10-4 overall and 2-1 on the road. Creighton is ranked third in the Big East; Xavier is ranked fourth. 

The Musketeers are favored by 9.5 points in the latest Xavier vs. Creighton odds from Caesars Sportsbook, and the over-under is set at 141. Before you make any Creighton vs. Xavier picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated Xavier vs. Creighton 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 70 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Xavier vs. Creighton? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!