The Chicago White Sox and Pittsburgh Pirates face off in an interleague day game on Wednesday afternoon. First pitch from PNC Park in Pittsburgh is at 12:35 p.m. ET. Chicago is listed as a -160 road favorite (risk $160 to win $100) in the latest White Sox vs. Pirates odds from William Hill Sportsbook, while the Over-Under for total runs scored is 8.5 (see the latest lines for every game on our MLB odds page).

Before making any White Sox vs. Pirates picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. It's off to a sizzling start in 2021, going 100-74 on top-rated MLB money-line picks through 12 weeks, returning over $1,200. Anyone following it has seen HUGE returns!

Now, it has set its sights on White Sox vs. Pirates. We can tell you it's leaning Over, and it also says one side of the money line has all the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins White Sox vs. Pirates? And which side of the money line has all the value? ... Join SportsLine right now to find out which side of the White Sox vs. Pirates money line you should be all over on Wednesday, all from the model that was up over $1,400 on MLB picks in 2019!