White Sox vs. Guardians odds, picks: Advanced computer MLB model releases selections for Tuesday matchup

The Chicago White Sox and Cleveland Guardians kick off a doubleheader at 1:10 p.m. ET on Tuesday. Cleveland is listed as a -160 favorite (risk $160 to win $100) at Caesars Sportsbook, while the Over-Under is set at eight (see up-to-date odds for every game this week on our MLB odds page). 

Before making any White Sox vs. Guardians picks, you NEED to check out the MLB predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is 275-236 on top-rated MLB money-line picks since the start of the 2021 season, returning over $400 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

The model knows the White Sox are above-average on offense. Chicago lands above the AL median in runs scored and on-base percentage, with top-five marks in hits and batting average. The White Sox also strike out in less than 21 percent of their plate appearances. 2022 All-Star Tim Anderson anchors a squad that is deep and talented. 

The model also knows the Guardians have a bonafide superstar in Jose Ramirez. Ramirez, who was just selected to his fourth All-Star Game, leads the AL in doubles and RBI this season. He is the centerpiece of a Cleveland offense that ranks in the top five of the AL in doubles, triples, and stolen bases. The Guardians also lead the AL in strikeout avoidance on offense.

Now, it has set its sights on White Sox vs. Guardians. We can tell you the model is leaning Over the total, and it also says one team has ALL the value! You ABSOLUTELY need to see it before locking in any MLB picks.

Who wins White Sox vs. Guardians? And which team has ALL the value on the money line? ... Join SportsLine right now to find out which side of the White Sox vs. Guardians matchup you should be all over Tuesday, all from the model on a roll on MLB picks!